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Titolo:
Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance
Autore:
Fan, GC; Wu, CT;
Indirizzi:
Beijing Inst Radiat Med, Dept Expt Hematol, Beijing 100850, Peoples R China Beijing Inst Radiat Med Beijing Peoples R China 100850 , Peoples R China
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 158, anno: 2000,
pagine: 203 - 210
SICI:
0304-3835(20001001)158:2<203:TOPGID>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARF TUMOR-SUPPRESSOR; STABILIZES P53; INK4A LOCUS; MDM2; P19(ARF); P16(INK4A); PRODUCT; ARREST; TRANSCRIPT; EXPRESSION;
Keywords:
p14ARF; MDR-1; P-glycoprotein; doxorubicin; breast cancer; tumor suppression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, CT Beijing Inst Radiat Med, Dept Expt Hematol, 27 Tai Ping Rd, Beijing100850, Peoples R China Beijing Inst Radiat Med 27 Tai Ping Rd Beijing Peoples R China 100850
Citazione:
G.C. Fan e C.T. Wu, "Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance", CANCER LETT, 158(2), 2000, pp. 203-210

Abstract

The INR4a/ARF locus on human chromosome 9p21 encodes two tumor suppressors, p16INK4a and p14ARF, that restrain cell growth by affecting the functionsof the retinoblastoma protein and p53. respectively. Overexpression of ARFresults in cell cycle arrest in both G1 and G2. To elucidate the effect ofp14ARF gene on multidrug-resistant tumor cells, we transferred a p14ARF cDNA into p53-mutated MCF-7/Adr human breast cancer cells. In this report we demonstrated for the first time that p14ARF expression was able to greatly inhibit the MCF-7/Adr cell proliferation. Furthermore, p14ARF expression resulted in decrease of MDR-1 mRNA and P-glycoprotein production, which linked to the reducing resistance of MCF-7/Adr cells to doxorubicin. These results imply that drug resistance might be effectively reversed by the wild-type p14ARF expression in human breast cancer cells. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:33:11