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Titolo:
Chemopreventive activity of hydroksymatairesinol in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice
Autore:
Oikannen, SI; Pajari, AM; Mutanen, M;
Indirizzi:
Univ Helsinki, Dept Appl Chem & Microbiol Nutr, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 tr, FIN-00014 Helsinki, Finland
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 159, anno: 2000,
pagine: 183 - 187
SICI:
0304-3835(20001031)159:2<183:CAOHIA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN; PHYTO-ESTROGENS; CANCER; LIGNANS; COLON; ACTIVATION;
Keywords:
hydroxymatairesinol; rye; intestinal polyps; Apc(Min) mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Mutanen, M Univ Helsinki, Dept Appl Chem & Microbiol Nutr, POB 27, FIN-00014 Helsinki, Finland Univ Helsinki POB 27 Helsinki Finland FIN-00014 sinki, Finland
Citazione:
S.I. Oikannen et al., "Chemopreventive activity of hydroksymatairesinol in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice", CANCER LETT, 159(2), 2000, pp. 183-187

Abstract

We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestinewas significantly lower (26.6 +/- 11.0, P < 0.05) in mice fed the TNS tumor promoter insulin and HMR when compared with the insulin and insulin/rye bran fed mice (39.6 +/- 8.9 and 36.0 +/- 7.4, respectively). HMR resulted innormalization of <beta>-catenin levels in adenoma tissue, indicating that HMR mediates its chemopreventive effect through the Apc-beta -catenin pathway. In the cytosolic fraction, beta -catenin level in adenoma tissue was significantly elevated (P = 0.008-0.013) in all the diet groups as compared with that of the surrounding mucosa. In the nuclear fraction, beta -catenin in the insulin (3.15 +/- 2.9 relative units) and insulin/rye (5.17 +/- 6.94relative units) groups was also significantly higher (P = 0.003-0.009) in the adenoma tissue when compared with the surrounding mucosa (0.5 +/- 0.5 and 0.35 +/- 0.39 relative units). However, HMR was able to restore nuclear beta -catenin level of the adenoma tissue (0.41 +/- 0.25 relative units) tothe level found in the surrounding mucosa (0.36 +/- 0.28 relative units). (C) 2000 Published by Elsevier Science Ireland Ltd, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:00:54