Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Associations between smoking and adenocarcinomas and squamous cell carcinomas of the uterine cervix (United States)
Autore:
Lacey, JV; Frisch, M; Brinton, LA; Abbas, FM; Barnes, WA; Gravitt, PE; Greenberg, MD; Greene, SM; Hadjimichael, OC; McGowan, L; Mortel, R; Schwartz, PE; Zaino, RJ; Hildesheim, A;
Indirizzi:
NCI, Div Canc Epidemiol & Genet, Environm Epidemiol Branch, Hormonal Studies Sect, Rockville, MD 20852 USA NCI Rockville MD USA 20852 Hormonal Studies Sect, Rockville, MD 20852 USA Statens Serum Inst, Dept Epidemiol Res, Danish Epidemiol Sci Ctr, DK-2300 Copenhagen, Denmark Statens Serum Inst Copenhagen Denmark DK-2300 K-2300 Copenhagen, Denmark Sinai Hosp, Baltimore, MD 21215 USA Sinai Hosp Baltimore MD USA 21215Sinai Hosp, Baltimore, MD 21215 USA Georgetown Univ, Lombardi Canc Ctr, Washington, DC USA Georgetown Univ Washington DC USA Lombardi Canc Ctr, Washington, DC USA Roche Mol Syst Inc, Alameda, CA USA Roche Mol Syst Inc Alameda CA USARoche Mol Syst Inc, Alameda, CA USA Univ Penn, Grad Hosp, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Grad Hosp, Philadelphia, PA 19104 USA Westat Inc, Rockville, MD USA Westat Inc Rockville MD USAWestat Inc, Rockville, MD USA Yale Univ, Sch Med, New Haven, CT USA Yale Univ New Haven CT USAYale Univ, Sch Med, New Haven, CT USA George Washington Univ, Div Gynecol Oncol, Washington, DC USA George Washington Univ Washington DC USA necol Oncol, Washington, DC USA Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 rshey Med Ctr, Hershey, PA 17033 USA
Titolo Testata:
CANCER CAUSES & CONTROL
fascicolo: 2, volume: 12, anno: 2001,
pagine: 153 - 161
SICI:
0957-5243(200102)12:2<153:ABSAAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-PAPILLOMAVIRUS INFECTION; RISK-FACTORS; CIGARETTE-SMOKING; INTRAEPITHELIAL NEOPLASIA; ORAL-CONTRACEPTIVES; ENDOMETRIAL CANCER; EPIDEMIOLOGY; NONSMOKERS; SMOKERS; WOMEN;
Keywords:
cervical adenocarcinomas; confounding; human papillomaviruses; smoking; tobacco;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Lacey, JV NCI, Div Canc Epidemiol & Genet, Environm Epidemiol Branch, Hormonal Studies Sect, 6120 Execut Blvd,MSC 7234, Rockville, MD 20852 USA NCI 6120 Execut Blvd,MSC 7234 Rockville MD USA 20852 D 20852 USA
Citazione:
J.V. Lacey et al., "Associations between smoking and adenocarcinomas and squamous cell carcinomas of the uterine cervix (United States)", CANC CAUSE, 12(2), 2001, pp. 153-161

Abstract

Objectives: Few studies of smoking and cervical carcinoma have addressed the rare cervical adenocarcinomas or used DNA-based tests to control for human papillomavirus (HPV) infection. Methods: This multicenter case-control study included 124 adenocarcinoma cases, 307 community controls (matched on age, race, and residence to adenocarcinoma cases), and 139 squamous carcinoma cases (matched on age, diagnosis date, clinic, and disease stage to adenocarcinoma cases). Participants completed risk-factor interviews and volunteered cervical samples for PCR-based HPV testing. Polychotomous logistic regression generated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for both histologic types. Results: Eighteen percent of adenocarcinoma cases, 43% of squamous carcinoma cases, and 22% of controls were current smokers. After control for HPV and other questionnaire data, adenocarcinomas were consistently inversely associated with smoking (e.g. current: OR = 0.6, 95% CI 0.3-1.1; greater thanor equal to1 pack per day: OR = 0.7, 95% CI 0.4-1.3), while squamous carcinomas were positively associated with smoking (e.g. current: OR = 1.6, 95% CI 0.9-2.9; greater than or equal to1 pack per day: OR = 1.8, 95% CI 1.0-3.3). Results in analyses restricted to HPV-positive controls were similar. Conclusion: Smoking has opposite associations with cervical adenocarcinomas and squamous carcinomas. Although both histologic types are caused by HPVand arise in the cervix, etiologic co-factors for these tumors may differ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 09:01:00