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Titolo:
Effects of mammographic density and benign breast disease on breast cancerrisk (United States)
Autore:
Byrne, C; Schairer, C; Brinton, LA; Wolfe, J; Parekh, N; Salane, M; Carter, C; Hoover, R;
Indirizzi:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp, Channing Lab, Boston, MA 02115 USA NCI, Environm Epidemiol Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 vironm Epidemiol Branch, Bethesda, MD 20892 USA Wolfe Radiol Associates, Detroit, MI USA Wolfe Radiol Associates Detroit MI USA adiol Associates, Detroit, MI USA OncorMed, Gaithersburg, MD USA OncorMed Gaithersburg MD USAOncorMed, Gaithersburg, MD USA
Titolo Testata:
CANCER CAUSES & CONTROL
fascicolo: 2, volume: 12, anno: 2001,
pagine: 103 - 110
SICI:
0957-5243(200102)12:2<103:EOMDAB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARENCHYMAL PATTERNS; QUANTITATIVE-EVALUATION; FEMALE BREAST; FEATURES; WOMEN; CLASSIFICATION; TIME;
Keywords:
benign breast disease; breast cancer risk; mammographic density;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Byrne, C Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA Harvard Univ 181 Longwood Ave Boston MA USA 02115 n, MA 02115 USA
Citazione:
C. Byrne et al., "Effects of mammographic density and benign breast disease on breast cancerrisk (United States)", CANC CAUSE, 12(2), 2001, pp. 103-110

Abstract

Background: Having either a history of benign breast disease, particularlyatypical hyperplasia or extensive mammographic breast density, is associated with increased breast cancer risk. Previous studies have described an association between benign breast disease histology and breast density. However, whether these features measure the same risk, or are independent risk factors, has not been addressed. Methods: This case-control study, nested within the prospective follow-up of the Breast Cancer Detection Demonstration Project, evaluated both benignhistologic and mammographic density information from 347 women who later developed breast cancer and 410 age- and race-matched controls without breast cancer. Multivariate logistic regression analyses provided maximum-likelihood estimates of the odds ratios (OR) and 95% confidence intervals (CI) toevaluate the relative risk of breast cancer associated with each exposure. Results: Adjusting for mammographic density, the OR for atypical hyperplasia was 2.1 (95% CI: 1.3-3.6), and adjusting for benign breast histology, the OR for greater than or equal to 75% density was 3.8 (95% CI: 2.0-7.2). Women with nonproliferative benign breast disease and greater than or equal to 75% density had an OR of 5.8 (95% CI: 1.8-18.6), and women with < 50% density and atypical hyperplasia had an OR of 4.1 (95% CI: 2.1-8.0). Conclusions: In this study, both benign breast disease histology and the percentage of the breast area with mammographic density were associated withbreast cancer risk. However, women with both proliferative benign breast disease and greater than or equal to 75% density were not at as high a risk of breast cancer due to the combination of effects (p = 0.002) as women with only one of these factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:31:37