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Titolo:
Selective impairment of verb processing associated with pathological changes in Brodmann areas 44 and 45 in the motor neurone disease-dementia-aphasia syndrome
Autore:
Bak, TH; ODonovan, DG; Xuereb, JH; Boniface, S; Hodges, JR;
Indirizzi:
MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England MRC Cambridge England CB2 2EF Brain Sci Unit, Cambridge CB2 2EF, England Univ Cambridge, Neurol Unit, Cambridge, England Univ Cambridge CambridgeEngland ridge, Neurol Unit, Cambridge, England Addenbrookes Hosp, Dept Clin Neurophysiol, Cambridge, England AddenbrookesHosp Cambridge England in Neurophysiol, Cambridge, England Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP hol, Cambridge CB2 1QP, England
Titolo Testata:
BRAIN
, volume: 124, anno: 2001,
parte:, 1
pagine: 103 - 120
SICI:
0006-8950(200101)124:<103:SIOVPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; ALZHEIMERS-DISEASE; PRESENILE-DEMENTIA; FRONTOTEMPORAL DEMENTIA; DYNAMIC APHASIA; COMPREHENSION; RETRIEVAL; LANGUAGE; NOUNS; DISSOCIATION;
Keywords:
aphasia; frontotemporal dementia; motor neurone disease; verb processing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Hodges, JR MRC, Cognit & Brain Sci Unit, 15 Chaucer Rd, Cambridge CB2 2EF,England MRC 15 Chaucer Rd Cambridge England CB2 2EF e CB2 2EF, England
Citazione:
T.H. Bak et al., "Selective impairment of verb processing associated with pathological changes in Brodmann areas 44 and 45 in the motor neurone disease-dementia-aphasia syndrome", BRAIN, 124, 2001, pp. 103-120

Abstract

We report six patients with clinically diagnosed and electrophysiologically confirmed motor neurone disease (MND), in whom communication problems were an early and dominant feature. All patients developed a progressive non-fluent aphasia culminating in some cases in complete mutism. In five cases, formal testing revealed deficits in syntactic comprehension. Comprehension and production of verbs were consistently more affected those that of nounsand this effect remained stable upon subsequent testing, despite overall deterioration. The classical signs of MND, including wasting, fasciculationsand severe bulbar symptoms, occurred over the following 6-12 months. The behavioural symptoms ranged from mild anosognosia to personality change implicating frontal-lobe dementia, In three cases, post-mortem examination has confirmed the clinical diagnosis of MND-dementia. In addition to the typical involvement of motor and premotor cortex, particularly pronounced pathological changes were observed in the Brodmann areas 44 (Broca's area) and 45. The finding of a selective impairment of verb/action processing in association with the demential aphasia syndrome of MND suggests that the neural substrate underlying verb representation is strongly connected to anterior cortical motor systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:50:32