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Titolo:
Transplantation of CD34-enriched peripheral stem cells from an HLA-haplotype mismatched donor to a patient with severe aplastic anemia
Autore:
Kremens, B; Basu, O; Grosse-Wilde, H; Sauerwein, W; Schaefer, UW; Havers, W;
Indirizzi:
Univ Hosp, Dept Pediat Hematol Oncol & Endocrinol, W German Tumor Ctr, Essen, Germany Univ Hosp Essen Germany Endocrinol, W German Tumor Ctr, Essen, Germany Univ Hosp, Dept Immunol, W German Tumor Ctr, Essen, Germany Univ Hosp Essen Germany ept Immunol, W German Tumor Ctr, Essen, Germany Univ Hosp, Dept Radiotherapy, W German Tumor Ctr, Essen, Germany Univ Hosp Essen Germany adiotherapy, W German Tumor Ctr, Essen, Germany Univ Hosp, Dept Bone Marrow Transplant, W German Tumor Ctr, Essen, GermanyUniv Hosp Essen Germany Transplant, W German Tumor Ctr, Essen, Germany
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 1, volume: 27, anno: 2001,
pagine: 111 - 113
SICI:
0268-3369(200101)27:1<111:TOCPSC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIENCE; CHILDREN;
Keywords:
bone marrow transplantation; haploidentical; T cell depletion; severe aplastic anemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Kremens, B Univ Kinderklin, Hufelandstr 55, D-45122 Essen, Germany Univ Kinderklin Hufelandstr 55 Essen Germany D-45122 , Germany
Citazione:
B. Kremens et al., "Transplantation of CD34-enriched peripheral stem cells from an HLA-haplotype mismatched donor to a patient with severe aplastic anemia", BONE MAR TR, 27(1), 2001, pp. 111-113

Abstract

A 14-year-old girl developed very severe aplastic anemia unresponsive to steroids, cyclosporine, ATG and filgrastim, She experienced repeated bacterial infections, hypermenorrhagia and epistaxis and received numerous transfusions. Lacking a matched family or unrelated donor, she was transplanted 6 months after diagnosis with CD34(+) cell-enriched peripheral stem cells from her HLA-haploidentical uncle. Conditioning included fludarabine, cyclophosphamide, 800 cGy TLI and OKT3, Prompt and sustained trilineage engraftmentoccurred. Acute GVHD grade 1 and herpes esophagitis were successfully treated. Eight months after grafting she was well with stable hematopoiesis, She then succumbed to fulminant hepatic failure due to adenovirus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:59:09