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Titolo:
Transplant-related mortality in patients older than 60 years undergoing autologous hematopoietic stem cell transplantation
Autore:
de la Rubia, J; Saavedra, S; Sanz, GF; Martin, G; Moscardo, F; Martinez, J; Jarque, I; Jimenez, C; Sanz, MA;
Indirizzi:
Univ Hosp La Fe, Hematol Serv, Bone Marrow Transplant Unit, Valencia, Spain Univ Hosp La Fe Valencia Spain Marrow Transplant Unit, Valencia, Spain
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 1, volume: 27, anno: 2001,
pagine: 21 - 25
SICI:
0268-3369(200101)27:1<21:TMIPOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW-TRANSPLANTATION; ACUTE MYELOBLASTIC-LEUKEMIA; MULTIPLE-MYELOMA; COMPLETE REMISSION; FREE SURVIVAL; BLOOD; THERAPY; AGE; INTENSIFICATION; LYMPHOMA;
Keywords:
high-dose therapy; autologous stem eel transplantation; elderly patients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sanz, MA Univ Hosp La Fe, Hematol Serv, Bone Marrow Transplant Unit, Valencia, Spain Univ Hosp La Fe Valencia Spain ransplant Unit, Valencia, Spain
Citazione:
J. de la Rubia et al., "Transplant-related mortality in patients older than 60 years undergoing autologous hematopoietic stem cell transplantation", BONE MAR TR, 27(1), 2001, pp. 21-25

Abstract

Although high-dose therapy with autologous hematopoietic stem cell transplantation (ASCT) is a widely used method of dose intensification in patientswith hematological malignancies, patients aged over 60 are generally excluded, We evaluated high-dose therapy and ASCT in 29 cases involving 27 such patients (median age 63 years; range 61-68) with different malignancies, Patients were eligible if they had a good performance status, normal cardiac,respiratory, and hepatic function and a serum creatinine concentration of less than 2 mg/dl (<5 mg/dl in myeloma patients), Engraftment was assessable in 27 procedures. The median time to attain 0.5 and 1 x 10(9) PMN/l was 13 days (range 9-30) and 14 days (range 10-66), respectively, The median time taken to reach a platelet count greater than 50 x 10(9)/l was 14 days (range 8-223), Five patients (17%) died in the first 100 days after transplant, in two cases due to disease progression. The remaining three patients died as a consequence of transplant-related complications, with an overall transplant-related mortality of 10%, Five patients relapsed and died between 5and 36 months after transplant, The remaining 17 patients are still alive without disease progression, with an actuarial overall survival of 47 % at 42 months (95 % CI 33-61), We consider that high-dose therapy with ASCT should be considered in those elderly patients with good performance status and without general organ impairment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:18:55