Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation
Autore:
Utsunomiya, A; Miyazaki, Y; Takatsuka, Y; Hanada, S; Uozumi, K; Yashiki, S; Tara, M; Kawano, F; Saburi, Y; Kikuchi, H; Hara, M; Sao, H; Morishima, Y; Kodera, Y; Sonoda, S; Tomonaga, M;
Indirizzi:
Imamura Bun In Hosp, Dept Hematol, Kagoshima 8900064, Japan Imamura Bun InHosp Kagoshima Japan 8900064 ol, Kagoshima 8900064, Japan Nagasaki Univ, Inst Atom Dis, Dept Hematol, Mol Med Unit, Nagasaki 852, Japan Nagasaki Univ Nagasaki Japan 852 atol, Mol Med Unit, Nagasaki 852, Japan Kagoshima Univ, Fac Med, Dept Internal Med 2, Kagoshima 890, Japan Kagoshima Univ Kagoshima Japan 890 Internal Med 2, Kagoshima 890, Japan Kagoshima Univ, Fac Med, Dept Virol, Kagoshima 890, Japan Kagoshima Univ Kagoshima Japan 890 Med, Dept Virol, Kagoshima 890, Japan Kagoshima City Hosp, Kagoshima, Japan Kagoshima City Hosp Kagoshima Japan goshima City Hosp, Kagoshima, Japan Kumamoto Natl Hosp, Inst Clin Res, Kumamoto, Japan Kumamoto Natl Hosp Kumamoto Japan Hosp, Inst Clin Res, Kumamoto, Japan Oita Prefectural Hosp, Dept Hematol, Oita, Japan Oita Prefectural Hosp Oita Japan ctural Hosp, Dept Hematol, Oita, Japan Oita Med Univ, Blood Transfus Serv, Oita, Japan Oita Med Univ Oita Japan ita Med Univ, Blood Transfus Serv, Oita, Japan Ehime Prefectural Cent Hosp, Matsuyama, Ehime, Japan Ehime Prefectural Cent Hosp Matsuyama Ehime Japan atsuyama, Ehime, Japan Meitetsu Hosp, Dept Hematol, Nagoya, Aichi, Japan Meitetsu Hosp Nagoya Aichi Japan osp, Dept Hematol, Nagoya, Aichi, Japan Aichi Canc Ctr, Dept Hematol & Chemotherapy, Nagoya, Aichi, Japan Aichi Canc Ctr Nagoya Aichi Japan l & Chemotherapy, Nagoya, Aichi, Japan Japanese Red Cross Nagoya First Hosp, Div Hematol, Nagoya, Aichi, Japan Japanese Red Cross Nagoya First Hosp Nagoya Aichi Japan ya, Aichi, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 1, volume: 27, anno: 2001,
pagine: 15 - 20
SICI:
0268-3369(200101)27:1<15:IOOATC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; LEUKEMIA-LYMPHOMA; VIRUS TYPE-1; LYMPHOCYTES; RETROVIRUS;
Keywords:
ATL; allo-SCT; allo-BMT; allo-PBSCT; HTLV-I proviral DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Utsunomiya, A Imamura Bun In Hosp, Dept Hematol, Kamoikeshinmachi 11-23, Kagoshima 8900064, Japan Imamura Bun In Hosp Kamoikeshinmachi 11-23 Kagoshima Japan 8900064
Citazione:
A. Utsunomiya et al., "Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation", BONE MAR TR, 27(1), 2001, pp. 15-20

Abstract

Adult T cell leukemia/lymphoma (ATL) is a poor prognosis T cell malignancy. In order to improve the outcome, we employed allogeneic stem cell transplantation (allo-SCT) for ATL in 10 patients, nine of whom were from HLA-identical siblings and one from an unrelated donor, Conditioning regimens varied among the patients except that all received total body irradiation. The patients tolerated the regimens well with mild, if any toxicity, and engraftment occurred in all cases. Median leukemia-free survival after allo-SCT was 17.5+ months (range 3,7-34,4+), Six of the 10 patients developed acute GVHD tone case each with grade I, III or IV, and three cases with grade II) and three patients developed extensive chronic GVHD, Four patients died after allo-SCT during the study period from either acute GVHD (grade IV), pneumonitis, gastrointestinal bleeding or renal insufficiency. Two of the 10 cases with no symptoms of GVHD relapsed with clinical ATL, These results strongly suggest that allo-SCT may improve the survival in ATL if a controlled degree of GVHD develops.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:51:25