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Titolo:
Age, gender, and fragility fractures are associated with differences in quantitative ultrasound independent of bone mineral density
Autore:
Karlsson, MK; Duan, Y; Ahlborg, H; Obrant, KJ; Johnell, O; Seeman, E;
Indirizzi:
Univ Melbourne, Austin & Repatriat Med Ctr, Dept Endocrinol, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia crinol, Melbourne, Vic, Australia Malmo Univ Hosp, Dept Orthopaed, Malmo, Sweden Malmo Univ Hosp Malmo Sweden o Univ Hosp, Dept Orthopaed, Malmo, Sweden
Titolo Testata:
BONE
fascicolo: 1, volume: 28, anno: 2001,
pagine: 118 - 122
SICI:
8756-3282(200101)28:1<118:AGAFFA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY ABSORPTIOMETRY; CANCELLOUS BONE; POSTMENOPAUSAL WOMEN; VERTEBRAL BONE; HIP FRACTURE; OSTEOPOROSIS; ATTENUATION; DENSITOMETRY; ORIENTATION; VELOCITY;
Keywords:
bone mineral density (BMD); bone architecture; dual-energy X-ray absorptiometry (DXA); fractures; quantitative ultrasound (QUS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Seeman, E Univ Melbourne, Austin & Repatriat Med Ctr, Dept Endocrinol, Heidelberg, Vic 3084, Australia Univ Melbourne Heidelberg Vic Australia 3084 ic 3084, Australia
Citazione:
M.K. Karlsson et al., "Age, gender, and fragility fractures are associated with differences in quantitative ultrasound independent of bone mineral density", BONE, 28(1), 2001, pp. 118-122

Abstract

Bone strength is determined by bone mineral density (BMD) and bone structure. Dual-energy X-ray absorptiometry (DXA) measures BMD, Whether quantitative ultrasound (qUS) measures a property of bone distinct from BMD is uncertain, To evaluate this, DXA and qUS were measured in 58 fracture patients and 428 controls. To study the independent effects of age and gender on qUS measurements and control for BMD by study design rather than statistical methods, subgroups from the normative database were created and intentionally matched by the same femoral neck (FN) BMD, Speed of sound (SOS; m/sec), broadband ultrasound attenuation (BUA; dB/MHz), and stiffness index (SI) were then compared in individuals matched by FN BMD but differing in age, gender, and presence or absence of fractures. The results are presented as percentage difference (mean +/- SD). Elderly women with the same FN BMD as young women had 1 +/- 2% lower SOS (p < 0.05), 8 +/- 15% lower SI (p < 0.05), and4 +/- 9% lower BUA (p = 0.07), Elderly women with the same FN BMD as elderly men had 5 a 9% lower BUA (p < 0.05), Elderly men with the same FN BMD asyoung men had 1 a 2% lower SOS (p = 0.1), 5 +/- 14% lower SI (p = 0.2), and 1 a 9% lower BUA (n.s.), Young women with the same FN BMD as young men had 2 +/- 7% lower BUA (n.s.). Women with fragility fractures had 8 +/- 11% lower BUA (p < 0.001) and 13 +/- 22% lower SI (p < 0.01) than controls with no fractures matched by FN BMD, age, and gender. Men with fragility fractures had 13 +/- 12% lower BUA (p < 0.01) and 16 +/- 19% lower SI (p < 0.05) than controls with no fractures matched by FN BMD, age, and gender. Despite comparable femoral neck BMD, qUS measurements differed according to age, gender, and fracture status, suggesting that qUS may provide additional information independent of femoral neck BMD, such as differences in connectivityor other properties yet to be identified. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:35:49