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Titolo:
Bone mass changes of tibial and vertebral bones in young and adult rats with collagen-induced arthritis
Autore:
Enokida, M; Yamasaki, D; Okano, T; Hagino, H; Morio, Y; Teshima, R;
Indirizzi:
Tottori Univ, Fac Med, Dept Orthoped Surg, Yonago, Tottori 6838504, Japan Tottori Univ Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan
Titolo Testata:
BONE
fascicolo: 1, volume: 28, anno: 2001,
pagine: 87 - 93
SICI:
8756-3282(200101)28:1<87:BMCOTA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-6 ACTIVITY; RHEUMATOID-ARTHRITIS; CANCELLOUS BONE; FEMALE RATS; ADJUVANT; IMMOBILIZATION; ADAPTATION; MARROW; HISTOMORPHOMETRY; OSTEOPENIA;
Keywords:
rheumatoid arthritis (RA); collagen-induced arthritis (CIA); peripheral quantitative computed tomography; (pQCT); histomorphometry; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Enokida, M Tottori Univ, Fac Med, Dept Orthoped Surg, Yonago, Tottori 6838504, Japan Tottori Univ Yonago Tottori Japan 6838504 ttori 6838504, Japan
Citazione:
M. Enokida et al., "Bone mass changes of tibial and vertebral bones in young and adult rats with collagen-induced arthritis", BONE, 28(1), 2001, pp. 87-93

Abstract

To study the effect of arthritis on bone mass, bone mineral density (BMD) of cancellous and cortical bone in the tibial metaphysis and diaphysis in 2- and 7-month-old rats with collagen-induced arthritis (CIA) was serially measured using peripheral quantitative computed tomography (pQCT), BMD in the fourth lumbar vertebra in 7-month-old CIA rats was also measured by pQCT,The fourth lumbar vertebral body, distal femur, and proximal tibia in 7-month-old CIA rats were analyzed histomorphometrically. Changes in BMD differed between 2-month-old (young) and 7-month-old (adult) CIA rats. Although the BMD for the proximal tibia (2 mm and 5 mm distal from the growth cartilage) in young CIA rats decreased compared with that in control rats, the values exceeded the initial value during the arthritis course. On the other hand, bone loss in adult CIA rats occurred predominantly in the cancellous bone of the periarticular region of the tibia (2 mm distal from the growth cartilage), in which the enhancement of bone resorption and reduced bone formation were observed histomorphometrically. No remarkable changes were demonstrated in BMD or histomorphometric al analysis for the lumbar vertebra during the experimental course. These results suggest that bone loss in adult CIA rats resembles the osteoporosis that develops during the early stage ofhuman rheumatoid arthritis. We conclude that adult CIA rats are more appropriate than young CIA rats as an experimental model of secondary osteoporosis due to rheumatoid arthritis. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:53:21