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Titolo:
Tie2 ligands angiopoietin-1 and angiopoietin-2 are coexpressed with vascular endothelial cell growth factor in growing human bone
Autore:
Horner, A; Bord, S; Kelsall, AW; Coleman, N; Compston, JE;
Indirizzi:
Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Cambridge CB2 2QQ, EnglandUniv Cambridge Cambridge England CB2 2QQ hol, Cambridge CB2 2QQ, England Univ Cambridge, Sch Clin Med, Dept Med, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ Med, Cambridge CB2 2QQ, England Univ Cambridge, Sch Clin Med, Dept Paediat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ iat, Cambridge CB2 2QQ, England
Titolo Testata:
BONE
fascicolo: 1, volume: 28, anno: 2001,
pagine: 65 - 71
SICI:
8756-3282(200101)28:1<65:TLAAAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; ANGIOGENESIS; EXPRESSION; CARTILAGE; VEGF; MATURATION; SURVIVAL;
Keywords:
angiopoietin; VEGF; human; bone; angiogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Horner, A Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Med, Box 157,Level 5,Hills Rd, Cambridge CB2 2QQ, England Univ Cambridge Box 157,Level 5,Hills Rd Cambridge England CB2 2QQ
Citazione:
A. Horner et al., "Tie2 ligands angiopoietin-1 and angiopoietin-2 are coexpressed with vascular endothelial cell growth factor in growing human bone", BONE, 28(1), 2001, pp. 65-71

Abstract

Angiogenesis is essential for bone growth and repair. Recent studies have shown that the endothelial-specific mitogen vascular endothelial growth factor (VEGF) is a key regulator of vascular invasion into the growth plate ininfant and adolescent animals. In order to identify mechanisms regulating VEGF-induced angiogenesis in growing bone, we have investigated the expression of the angiopoietins (Ang-1 and Ang-2) in human neonatal ribs. Ang-1 and Ang-2 exhibited similar patterns of staining in the growing rib. In the cartilage, expression of Ang-1 and Ang-2 increased with chondrocyte maturation. Ang-1, Ang-2, and VEGF were not detected in the resting zone except adjacent to vascular canals, and maximum expression was detected at the cartilage bone interface. In the cartilage, Ang-2 was more highly expressed than Ang-1 or VEGF, with staining observed in the proliferating, hypertrophic, and mineralized zones, In the bone, Ang-1, Ang-2, and VEGF were detected in modeling and remodeling sites. Ang-1 was detected in the majority of osteoblasts, osteoclasts, and in some marrow space cells. Ang-2 was expressed at variable levels by osteoblasts and osteoclasts in modeling and remodeling bone. VEGF was detected in tells at bone surfaces and in the marrow spaces. Strong staining for VEGF was observed in osteoblasts and osteoclasts in modeling and remodeling bone. In the perichondrium, Ang-1, Ang-2, and VEGF were most highly expressed adjacent to the hypertrophic zone and at sites of bone collar formation. In the periosteum, Ang-1, Ang-2, and VEGF expression colocalized with alkaline phosphatase expression. These observations provide the first evidence for the expression of the angiopoietins in growing human bone in vivo. The distribution of Ang-1, Ang-2, and VEGF indicate these factors may play key roles in the regulation of angiogenesis at sites of endochondral ossification, intramembranous ossification, and bone turnover inthe growing human skeleton, (C) 2001 by Elsevier Science inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 15:00:21