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Titolo:
The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts
Autore:
Chae, HJ; Chae, SW; Chin, HY; Bang, BG; Cho, SB; Han, KS; Kim, SC; Tae, KC; Lee, KH; Kim, DE; Im, MK; Lee, SJ; Chang, JY; Lee, YM; Kim, HM; Kim, HH; Lee, ZH; Kim, HR;
Indirizzi:
Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Wonkwang Univ, Sch Dent, Wonkwang Dent Res Inst, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Dent, Dept Oral Med, Iksan 570749, Chonbuk, South KoreaWonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Dent, Dept Orthodont, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Dent, Dept Pediat Dent, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Dent, Dept Conservat Dent, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Wonkwang Univ, Ctr Oriental Med Sci, Coll Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Chonbuk Natl Univ, Sch Med, Dept Pharmacol, Cardiovasc Res Inst, Chonbuk, South Korea Chonbuk Natl Univ Chonbuk South Korea sc Res Inst, Chonbuk, South Korea Chosun Univ, Natl Res Lab Bone Metab, Kwangju 501759, South Korea Chosun Univ Kwangju South Korea 501759 etab, Kwangju 501759, South Korea Chosun Univ, Res Ctr Proteinous Mat, Kwangju 501759, South Korea Chosun Univ Kwangju South Korea 501759 Mat, Kwangju 501759, South Korea
Titolo Testata:
BONE
fascicolo: 1, volume: 28, anno: 2001,
pagine: 45 - 53
SICI:
8756-3282(200101)28:1<45:TPMPKP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; CELLS ROS 17/2.8; FACTOR-ALPHA; BONE-RESORPTION; TNF-ALPHA; CYTOKINES; TRANSCRIPTION; IL-6; DIFFERENTIATION; INHIBITION;
Keywords:
tumor necrosis factur-alpha (TNF-alpha); interleukin-6; (IL-6); osteoblast; nuclear factor (NF)-kappa B; NF-kappa B inhibitor; p38 mitogen-activated protein kinase (MAPK);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HR Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 honbuk, SouthKorea
Citazione:
H.J. Chae et al., "The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts", BONE, 28(1), 2001, pp. 45-53

Abstract

The induction of interleukin-6 (IL-6), using a proinflammatory cytokine (tumor necrosis factor-alpha), was studied in a human osteoblast cell line (MG-63) in relation to p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB transcription factor. When added to MG-63 cells, tumornecrosis facltor-alpha (TNF-alpha) had a stimulatory effect on the production of IL-6, and this elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor. In addition, the stimulation of IL-6 release wasalso reduced by pyrrolidine dithiocarbamate (PDTC) or NF-kappaB SN50, which has been reported to be a potent NF-kappaB inhibitor. Both the NF-kappaB inhibitors in the presence of SB203580 had a more inhibitory effect on IL-6release. In this study, TNF-alpha stimulated NF-kappaB binding affinity aswell as p38 MAP kinase activation, leading to the release of IL-6, However, the specific inhibitor of p38 MAPK, SB203580, had no effect on TNF-alpha -induced NF-kappaB activation and both NF-kappaB inhibitors failed to reduce the p38 MAPK activation in the TNF-alpha -stimulated osteoblasts. In addition, inhibition of p38 MAPK partially, but significantly, impaired TNF-alpha -regulated release of osteocalcin, an important differentiation marker in osteoblasts. These results strongly suggest that both p38 MAPK and NF-kappaB are required in TNF-alpha -induced IL-6 synthesis and that these two TNF-alpha -activated pathways can be primarily dissociated. Furthermore, p38 MAPK may play a significant role in differentiation in MG-63 cells. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:31:12