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Titolo:
CD13/APN is activated by angiogenic signals and is essential for capillarytube formation
Autore:
Bhagwat, SV; Lahdenranta, J; Giordano, R; Arap, W; Pasqualini, R; Shapiro, LH;
Indirizzi:
St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 ol, Memphis, TN 38105 USA MD Anderson Res Hosp, Dept Med, Houston, TX USA MD Anderson Res Hosp Houston TX USA Res Hosp, Dept Med, Houston, TX USA
Titolo Testata:
BLOOD
fascicolo: 3, volume: 97, anno: 2001,
pagine: 652 - 659
SICI:
0006-4971(20010201)97:3<652:CIABAS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; AMINOPEPTIDASE-N; TRANSCRIPTIONAL ACTIVATION; SPINDLE CELLS; HYPOXIA; BINDING; GENE; IDENTIFICATION; PROLIFERATION; MORPHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Shapiro, LH St Jude Childrens Res Hosp, Dept Pathol, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp 332 N Lauderdale St Memphis TN USA 38105
Citazione:
S.V. Bhagwat et al., "CD13/APN is activated by angiogenic signals and is essential for capillarytube formation", BLOOD, 97(3), 2001, pp. 652-659

Abstract

In the hematopoietic compartment, the CD13/APN metalloprotease is one of the earliest markers of cells committed to the myeloid lineage where it is expressed exclusively on the surface of myeloid progenitors and their differentiated progeny. CD13/APN is also found in nonhematopoietic tissues, and its novel expression on the endothelial cells of angiogenic, but not normal,vasculature was recently described, Treatment of animals with CD13/APN inhibitors significantly impaired retinal neovascularization, chorioallantoic membrane angiogenesis, and xenograft tumor growth, indicating that CD13/APNplays an important functional role in vasculogenesis and identifying it asa critical regulator of angiogenesis. To investigate the mechanisms of CD13/APN induction in tumor vasculature, the regulation of CD13/APN by factorscontributing to angiogenic progression was studied, In this report, it is shown that endogenous CD13/APN levels in primary cells and cell lines are up-regulated in response to hypoxia, angiogenic growth factors, and signals regulating capillary tube formation during angiogenesis. Transcription of reporter; plasmids containing CD13/APN proximal promoter sequences is significantly increased in response to the same angiogenic signals that regulate the expression of the endogenous gene and in human tumor xenografts, indicating that this fragment contains elements essential for the angiogenic induction of CD13/APN expression, Finally, functional antagonists of CD13/APN interfere with tube formation but not proliferation of primary vascular endothelial cells, suggesting that CD13/APN functions in the control of endothelial cell morphogenesis. These studies clearly establish the CD13/APN metalloprotease as an important regulator of endothelial morphogenesis during angiogenesis. (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:12:17