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Titolo:
Nucleotide receptors: an emerging family of regulatory molecules in blood cells
Autore:
Di Virgilio, F; Chiozzi, P; Ferrari, D; Falzoni, S; Sanz, JM; Morelli, A; Torboli, M; Bolognesi, G; Baricordi, OR;
Indirizzi:
Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol & Med Genet, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 l & Med Genet, I-44100 Ferrara, Italy Univ Ferrara, Ctr Biotechnol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 tr Biotechnol, I-44100 Ferrara, Italy
Titolo Testata:
BLOOD
fascicolo: 3, volume: 97, anno: 2001,
pagine: 587 - 600
SICI:
0006-4971(20010201)97:3<587:NRAEFO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR ADENOSINE-TRIPHOSPHATE; NITRIC-OXIDE SYNTHASE; RAT MAST-CELLS; RAW-264.7 MURINE MACROPHAGES; HUMAN PHAGOCYTIC LEUKOCYTES; INDUCED PLATELET ACTIVATION; EPIDERMAL LANGERHANS CELLS; PURINERGIC P2X(7) RECEPTOR; MESSENGER-RNA EXPRESSION; HUMAN B-LYMPHOCYTES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
236
Recensione:
Indirizzi per estratti:
Indirizzo: Di Virgilio, F Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, Via Borsari 46, I-44100 Ferrara, Italy Univ Ferrara Via Borsari 46 Ferrara Italy I-44100 a, Italy
Citazione:
F. Di Virgilio et al., "Nucleotide receptors: an emerging family of regulatory molecules in blood cells", BLOOD, 97(3), 2001, pp. 587-600

Abstract

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules, It has been known for many years that adenosine diphosphate isa potent platelet aggregating factor, but it is now clear that virtually every circulating cell is responsive to nucleotides. Effects as different asproliferation or differentiation, chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular adenosine triphosphate (ATP). These effects are mediated through a specific class of plasma membrane receptors called purinergic P2 receptors that, according to the molecular structure, are further subdivided into 2 subfamilies: P2Y and P2X, ATP and possibly other nucleotides are released from damaged cells or secreted via nonlytic mechanisms, Thus, during inflammation or vascular damage, nucleotides may provide an important mechanism involved in the activation of leukocytes and platelets. However, the cell physiology of these receptors is still at its dawn, and the precise function of the multiple P2X and P2Y receptor subtypes remains to be understood. (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:36:42