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Titolo:
3,28-di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents
Autore:
Kashiwada, Y; Chiyo, J; Ikeshiro, Y; Nagao, T; Okabe, H; Cosentino, LM; Fowke, K; Lee, KH;
Indirizzi:
Niigata Coll Pharm, Niigata 9502081, Japan Niigata Coll Pharm Niigata Japan 9502081 l Pharm, Niigata 9502081, Japan Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 8140180, Japan Fukuoka Univ Fukuoka Japan 8140180 harmaceut Sci, Fukuoka 8140180, Japan BBI Biotech Res Labs, Gaithersburg, MD 20877 USA BBI Biotech Res Labs Gaithersburg MD USA 20877 Gaithersburg, MD 20877 USA Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA Univ NCarolina Chapel Hill NC USA 27599 d Lab, Chapel Hill, NC 27599 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 2, volume: 11, anno: 2001,
pagine: 183 - 185
SICI:
0960-894X(20010122)11:2<183:3IAAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIHYDROBETULINIC ACID-DERIVATIVES; BETULINIC ACID; AIDS AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Kashiwada, Y Niigata Coll Pharm, 5-13-2 Kamisinei Cho, Niigata 9502081, Japan Niigata Coll Pharm 5-13-2 Kamisinei Cho Niigata Japan 9502081
Citazione:
Y. Kashiwada et al., "3,28-di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents", BIOORG MED, 11(2), 2001, pp. 183-185

Abstract

Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3', 3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethylsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC50 value of 0.00087 muM and a TI value of 42,400. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 20:35:17