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Titolo:
Coating of Dacron vascular grafts with an ionic polyurethane: a novel sealant with protein binding properties
Autore:
Phaneuf, MD; Dempsey, DJ; Bide, MJ; Quist, WC; LoGerfo, FW;
Indirizzi:
Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA Beth Israel Deaconess Med Ctr Boston MA USA 02115 r, Boston, MA 02115 USA BioMod Surface, Salisbury, MA 01952 USA BioMod Surface Salisbury MA USA 01952 od Surface, Salisbury, MA 01952 USA Univ Rhode Isl, Dept Text, Kingston, RI 02881 USA Univ Rhode Isl KingstonRI USA 02881 l, Dept Text, Kingston, RI 02881 USA
Titolo Testata:
BIOMATERIALS
fascicolo: 5, volume: 22, anno: 2001,
pagine: 463 - 469
SICI:
0142-9612(200103)22:5<463:CODVGW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL PROSTHESES; BIOLOGICAL SEALANTS; KNITTED DACRON; COLLAGEN; INVITRO; SURFACE; SITES;
Keywords:
blood vessel prosthesis; Dacron; polyurethane; sealant; albumin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Phaneuf, MD Beth Israel Deaconess Med Ctr, 4 Blackfan Circle,HIM Bldg,Room131, Boston, MA 02115 USA Beth Israel Deaconess Med Ctr 4 Blackfan Circle,HIM Bldg,Room 131 Boston MA USA 02115
Citazione:
M.D. Phaneuf et al., "Coating of Dacron vascular grafts with an ionic polyurethane: a novel sealant with protein binding properties", BIOMATERIAL, 22(5), 2001, pp. 463-469

Abstract

The purpose of this study was to develop a novel sealant that would seal prosthetic vascular graft interstices and be accessible for protein binding. Crimped knitted Dacron vascular grafts were cleaned (CNTRL) and hydrolyzedin boiling sodium hydroxide (HYD). These HYD grafts were sealed using an 11% solids solution of a polyether-based urethane with carboxylic acid groups (PEU-D) via a novel technique that employs both trans-wall and luminal perfusion. Carboxylic acid content, determined via methylene blue dye uptake,was 2.3- and 4.2-fold greater in PEU-D segments (1.0 +/- 0.27 nmol/mg) as compared to HYD and CNTRL segments, respectively. Water permeation through PEU-D graft (1.1 +/- 2 ml/cm(2) min(-1)) was comparable to collagen-impregnated Dacron (9.8 +/- 10 ml/cm(2) min(-1)). Non-specific I-125-albumin (I-125-Alb) binding to PEU-D segments (18 +/- 3 ng/mg) was significantly lower than HYD and CNTRL segments. I-125-Alb linkage to PEU-D using the crosslinker EDC resulted in 5.7-fold greater binding (103 +/- 2 ng/mg) than non-specific PEU-D controls. However, covalent linkage of I-125-Alb to PEU-D was 4.9- and 5.9-fold less than CNTRL and HYD segments with EDC, respectively. Thus, ionic polyurethane can be applied to a pre-formed vascular graft, seal the interstices and create "anchor" sites for protein attachment. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:30:56