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Titolo:
Influence of the degree of stimulation of the pituitary by gonadotropin-releasing hormone on the action of inhibin and testosterone to suppress the secretion of the gonadotropins in rams
Autore:
Tilbrook, AJ; de Kretser, DM; Clarke, IJ;
Indirizzi:
Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia Monash Univ Clayton Vic Australia 3800 siol, Clayton, Vic 3800, Australia Monash Univ, Inst Reprod & Dev, Clayton, Vic 3800, Australia Monash Univ Clayton Vic Australia 3800 Dev, Clayton, Vic 3800, Australia Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res Clayton Vic Australia 3168 Vic 3168, Australia
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 2, volume: 64, anno: 2001,
pagine: 473 - 481
SICI:
0006-3363(200102)64:2<473:IOTDOS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONKEY MACACA-MULATTA; MALE RHESUS-MONKEY; RECOMBINANT HUMAN INHIBIN; MESSENGER-RIBONUCLEIC-ACID; BOVINE FOLLICULAR-FLUID; NEGATIVE FEEDBACK-REGULATION; PLASMA LUTEINIZING-HORMONE; OVARIECTOMIZED EWES; FSH-SECRETION; ADULT MALE;
Keywords:
anterior pituitary; FSH; GnRH; hormone action; inhibin; LH; testosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Tilbrook, AJ Monash Univ, Dept Physiol, POB 13F, Clayton, Vic 3800, Australia Monash Univ POB 13F Clayton Vic Australia 3800 800, Australia
Citazione:
A.J. Tilbrook et al., "Influence of the degree of stimulation of the pituitary by gonadotropin-releasing hormone on the action of inhibin and testosterone to suppress the secretion of the gonadotropins in rams", BIOL REPROD, 64(2), 2001, pp. 473-481

Abstract

This experiment determined if the degree of stimulation of the pituitary gland by GnRH affects the suppressive actions of inhibin and testosterone ongonadotropin secretion in rams. Two groups (n = 5) of castrated adult ramsunderwent hypothalamopituitary disconnection and were given two i.v. injections of vehicle or 0.64 mug/kg of recombinant human inhibin A (rh-inhibin)6 h apart when treated with i.m. injections of oil and testosterone propionate every 12 h for at least 7 days. Each treatment was administered when the rams were infused i.v. with 125 ng of GnRH every 4 h (i.e., slow-pulse frequency) and 125 ng of GnRH every hour (i.e., fast-pulse frequency). The FSH concentrations and LH pulse amplitude were lower and the LH concentrations higher during the fast GnRH pulse frequency. The GnRH pulse frequency did not influence the ability of rh-inhibin and testosterone to suppress FSH secretion. Testosterone did not affect LH secretion. Following rh-inhibin treatment, LH pulse amplitude decreased at the slow, but not at the fast, GnRH pulse frequency, and LH concentrations decreased at both GnRH pulse frequencies. We conclude that the degree of stimulation of the pituitary by GnRH does not influence the ability of inhibin or testosterone to suppress FSHsecretion in rams. Inhibin may be capable of suppressing LH secretion under conditions of low GnRH.

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Documento generato il 19/09/20 alle ore 09:06:52