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Titolo:
Vesicular monoamine transporter concentrations in bipolar disorder type I,schizophrenia, and healthy subjects
Autore:
Zubieta, JK; Taylor, SF; Huguelet, P; Koeppe, RA; Kilbourn, MR; Frey, KA;
Indirizzi:
Mental Hlth Res Inst, Dept Psychiat, Ann Arbor, MI 48104 USA Mental Hlth Res Inst Ann Arbor MI USA 48104 hiat, Ann Arbor, MI 48104 USA Univ Michigan, Dept Internal Med, Div Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Nucl Med, Ann Arbor, MI 48109 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 49, anno: 2001,
pagine: 110 - 116
SICI:
0006-3223(20010115)49:2<110:VMTCIB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; DOPAMINERGIC DRUG TREATMENTS; FUNCTIONAL BRAIN IMAGES; C-11 DIHYDROTETRABENAZINE; NEUROLEPTIC-NAIVE; SUBSTANTIA-NIGRA; BETA-CIT; VIVO; SEROTONIN; NEURONS;
Keywords:
dopamine; serotonin; VMAT2; schizophrenia; bipolar disorder; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Zubieta, JK Mental Hlth Res Inst, Dept Psychiat, Neurosci Bldg,1103 E Huron St, Ann Arbor, MI 48104 USA Mental Hlth Res Inst Neurosci Bldg,1103 E Huron St Ann Arbor MI USA 48104
Citazione:
J.K. Zubieta et al., "Vesicular monoamine transporter concentrations in bipolar disorder type I,schizophrenia, and healthy subjects", BIOL PSYCHI, 49(2), 2001, pp. 110-116

Abstract

Background: Previous analyses of vesicular monoamine transporter (VMAT2) binding in euthymic bipolar disorder type I (BDI) patients have shown increases of this presynaptic marker in the thalamus and ventral midbrain. To assess the diagnostic specificity of those findings, Mle compared VMAT2 concentrations between euthymic BDI patients, patients diagnosed with schizophrenia (SCH), and age-matched healthy volunteers. Methods: Binding sites far VMAT2 were quantified with (+)-alpha-[C-11]DTBZ(dihydrotetrabenazine) and positron emission tomography. Fifteen euthymic BDI and 12 SCH patients and 15 group-matched healthy controls were studied [C-11]DTBZ tracer transport and binding potentials were examined in the thalamus and ventral midbrain with factorial analyses of variance and post hocTukey's honestly significantly different tests. Results: Analysis of variance detected diagnosis effects in binding potentials in both brain regions. Binding of VMAT2 in the thalamus was higher in BDI patients than in control subjects and SCH patients, Conversely: ventralbrainstem binding was nearly identical between BDI and SCH patients and were higher than in the control group. Conclusions: The patterns of regional VMAT2 expression, and by extension, the concentration of monoaminergic synaptic terminals, differ between BDI, SCH, and a control group. These findings may relate to both similarities and differences in the presentation or clinical course of these syndromes andrequire further examination. (C) 2001 Society of Biological Psychiatry.

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Documento generato il 07/08/20 alle ore 06:27:10