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Titolo:
Spectrin: the ghost in the machine
Autore:
Thomas, GH;
Indirizzi:
Penn State Univ, Dept Biol, Mueller Lab 208, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 8, University Pk, PA 16802 USA Penn State Univ, Dept Biochem & Mol Biol, Mueller Lab 208, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 8, University Pk, PA 16802 USA
Titolo Testata:
BIOESSAYS
fascicolo: 2, volume: 23, anno: 2001,
pagine: 152 - 160
SICI:
0265-9247(200102)23:2<152:STGITM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL BRUSH-BORDER; CAENORHABDITIS-ELEGANS MORPHOGENESIS; CELL-SHAPE CHANGES; F-ACTIN-BINDING; RED-BLOOD-CELL; MEMBRANE SKELETON; EPITHELIAL-CELLS; ALPHA-SPECTRIN; BETA-SPECTRIN; DROSOPHILA-MELANOGASTER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, GH Penn State Univ, Dept Biol, Mueller Lab 208, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 ty Pk, PA 16802 USA
Citazione:
G.H. Thomas, "Spectrin: the ghost in the machine", BIOESSAYS, 23(2), 2001, pp. 152-160

Abstract

It has long been speculated that spectrin, the actin crosslinking and molecular scaffold protein, is involved in the development of apicobasal polarity in epithelia. While spectrins can undoubtedly influence the protein content of specific membrane domains, recent genetic evidence indicates that this activity is not necessary for the establishment or maintenance of this axis. Instead, these studies point to critical roles in tissue stability andmorphogenesis. A possible role in cellular contractility is highlighted inthis review. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:08:31