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Titolo:
A cluster of Drosophila homeobox genes involved in mesoderm differentiation programs
Autore:
Jagla, K; Bellard, M; Frasch, M;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Biochem & Mol Biol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 Biol, New York, NY 10029 USA Inst Genet & Biol Mol & Cellulaire, Illkirch, France Inst Genet & Biol Mol& Cellulaire Illkirch France re, Illkirch, France INSERM, U384, Clermont Ferrand, France INSERM Clermont Ferrand FranceINSERM, U384, Clermont Ferrand, France
Titolo Testata:
BIOESSAYS
fascicolo: 2, volume: 23, anno: 2001,
pagine: 125 - 133
SICI:
0265-9247(200102)23:2<125:ACODHG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ONCOGENE; HEART DEVELOPMENT; BITHORAX COMPLEX; DORSAL MESODERM; PRECURSOR CELLS; HOXD COMPLEX; EXPRESSION; SPECIFICATION; TINMAN; LADYBIRD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Frasch, M CUNY Mt Sinai Sch Med, Dept Biochem & Mol Biol, Box 1020,1 Gustave L Levy Pl, New York, NY 10029 USA CUNY Mt Sinai Sch Med Box 1020,1 Gustave L Levy Pl New York NY USA 10029
Citazione:
K. Jagla et al., "A cluster of Drosophila homeobox genes involved in mesoderm differentiation programs", BIOESSAYS, 23(2), 2001, pp. 125-133

Abstract

Although genes involved in common developmental programs are usually scattered throughout the metazoan genome, there are some important examples of functionally interconnected regulatory genes that display close physical linkage, In particular the homeotic genes, which determine the identities of body parts, are clustered in the Hox complexes and clustering is thought to be crucial for the proper execution of their developmental programs, Here we describe the organization and functional properties of a more recently identified cluster of six homeobox genes at 93DE on the third chromosome of Drosophila, These genes, which include tinman, bagpipe, ladybird early, ladybird late, C15, and slouch, all participate in mesodermal patterning and differentiation programs and show multiple regulatory interactions among eachother. We propose that their clustering, through unknown mechanisms, is functionally significant and discuss the similarities and differences betweenthe 93DE homeobox gene cluster and the Hox complexes. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:26:52