Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of high-density lipoprotein on cholesterol transport and acyl-coenzyme A: cholesterol acyltransferase activity in P388D1 macrophages
Autore:
Li, L; Pownall, HJ;
Indirizzi:
Baylor Coll Med, Dept Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Med, Dept Med, Houston, TX 77030 USA Baylor Coll Med, Cardiovasc Sci Grad Program, DeBakey Heart Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 key Heart Ctr, Houston, TX 77030 USA Methodist Hosp, Houston, TX 77030 USA Methodist Hosp Houston TX USA 77030Methodist Hosp, Houston, TX 77030 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 1, volume: 1530, anno: 2001,
pagine: 111 - 122
SICI:
1388-1981(20010115)1530:1<111:EOHLOC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING CASSETTE TRANSPORTER-1; MONOCYTE-DERIVED MACROPHAGES; CORONARY-ARTERY DISEASE; HAMSTER OVARY CELLS; SMOOTH-MUSCLE CELLS; APOLIPOPROTEIN-A-I; PROTEIN-KINASE-C; RECEPTOR SR-BI; TANGIER-DISEASE; CELLULAR CHOLESTEROL;
Keywords:
cholesteryl ester; macrophage; high-density lipoprotein; cholesterol transport; acyl-coenzyme A; cholesterol acyltransferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Pownall, HJ Baylor Coll Med, Dept Med, Mail Stn A601, Houston, TX 77030 USA Baylor Coll Med Mail Stn A601 Houston TX USA 77030 X 77030 USA
Citazione:
L. Li e H.J. Pownall, "Effects of high-density lipoprotein on cholesterol transport and acyl-coenzyme A: cholesterol acyltransferase activity in P388D1 macrophages", BBA-MOL C B, 1530(1), 2001, pp. 111-122

Abstract

High-density lipoproteins are the putative vehicles for cholesterol removal from monocyte-derived macrophages, which are an important cell type in all stages of atherosclerosis. The role of HDL2, an HDL subclass that accounts for most variation in plasma HDL-cholesterol concentration, in cholesterol metabolism in monocyte-derived macrophages is not known. In this study, the dose-dependent effects of HDL2 on cellular cholesterol mass, efflux, andesterification, and on cellular cholesteryl ester (CE) hydrolysis using the mouse macrophage P388D1 cell line was investigated. HDL2 at low concentrations (40 mug protein/ml) decreased CE content without affecting cellular free cholesterol content (FC), CE hydrolysis, or cholesterol biosynthesis. In addition, HDL2 at low concentrations reduced cellular acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity and increased FC efflux from macrophages. Thus, HDL2 has two potential roles in reverse cholesterol transport. In one, HDL2 is an acceptor of macrophage FC. In the other, more novel role, HDL2 increases the availability of macrophage FC through the inhibitionof ACAT. Elucidation of the mechanism by which HDL2 inhibits ACAT could identify new therapeutic targets that enhance the transfer of cholesterol from macrophages to the liver. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:45:40