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Titolo:
Signal characteristics of multichannel epicardial electrograms in chronic ischaemic and scarred myocardium: electromechanical mismatch indicates viability in regions of myocardial dysfunction
Autore:
Bruns, HJ; Janssen, FW; Schafers, M; Hammel, D; Fetsch, T; Arslan, O; Krenz, M; Vahlhaus, C; Borggrefe, M; Scheld, HH; Schober, O; Breithardt, G; Wichter, T;
Indirizzi:
Univ Munster, Med Klin & Poliklin, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 Poliklin, D-48129 Munster, Germany Univ Munster, Dept Cardiothorac Surg, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 orac Surg, D-48129 Munster, Germany Univ Munster, Dept Nucl Med, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 Nucl Med, D-48129 Munster, Germany
Titolo Testata:
BASIC RESEARCH IN CARDIOLOGY
fascicolo: 1, volume: 96, anno: 2001,
pagine: 98 - 105
SICI:
0300-8428(200102)96:1<98:SCOMEE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; LEFT-VENTRICULAR DYSFUNCTION; HIBERNATING MYOCARDIUM; F-18 FLUORODEOXYGLUCOSE; GLUCOSE-UTILIZATION; POTENTIALS; INFARCTION; DISTRIBUTIONS; REINJECTION; PERFUSION;
Keywords:
ischaemia; dyskinesia; epicardial mapping; electrocardiography; viability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Bruns, HJ Univ Munster, Med Klin & Poliklin, D-48129 Munster, Germany UnivMunster Munster Germany D-48129 D-48129 Munster, Germany
Citazione:
H.J. Bruns et al., "Signal characteristics of multichannel epicardial electrograms in chronic ischaemic and scarred myocardium: electromechanical mismatch indicates viability in regions of myocardial dysfunction", BAS R CARD, 96(1), 2001, pp. 98-105

Abstract

Background To predict the outcome after myocardial revascularisation, a clear separation between hibernation and/or repetitive stunning on the one hand and myocardial scarring on the other hand is of importance. Methods and results A total of 44 patients was included in this study. In 35 patients with chronic myocardial ischaemia and an indication for coronary bypass-surgery, epicardial mapping of local activation was performed. Nine patients with LV aneurysm and an indication for antitachycardia surgery were also included. For simultaneous recording of the local electrograms during sinus rhythm, a sock electrode with 102 bipolar leads was used. The regional myocardial contraction pattern was assessed from preoperative angiograms and regional myocardial metabolism (viability) from F-18-FDG PET, respectively. The results were projected on the grid of the intraoperative position of the sock electrode. This enabled regional comparison of electrogram characteristics to local contraction patterns and viability. For the characterisation of local electrograms, peak-to-peak amplitude andduration of activation were calculated using custom-made automated computer-algorithms. Dysfunctional but viable areas showed normal or almost normalelectrographic signal characteristics. In contrast, dysfunctional and non-viable myocardium showed a distinct reduction of local amplitudes and prolongation of signal duration. These changes were even more intense in areas of LV aneurysms. Conclusions In patients with chronic ischaemic myocardium, a mismatch between mechanical function and local electrogram characteristics was observed in areas with preserved metabolism. Thus, normal epicardial electrograms in regions of myocardial dysfunction may be an indicator for myocardial viability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 00:34:40