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Titolo:
The effect of various durations of noise exposure on auditory brainstem response, distortion product otoacoustic emissions and transient evoked otoacoustic emissions in rats
Autore:
Fraenkel, R; Freeman, S; Sohmer, H;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, IL-91120 Jerusalem,Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 L-91120 Jerusalem,Israel
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 40 - 49
SICI:
1420-3030(200101/02)6:1<40:TEOVDO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORARY THRESHOLD SHIFT; HAIR CELL LOSS; ACOUSTIC DISTORTION; GUINEA-PIG; EAR; INNER; CARBOPLATIN; CHINCHILLAS; ANIMALS; SOUND;
Keywords:
noise; hearing loss; auditory brainstem response; distortion product otoacoustic emission transient evoked otoacoustic emission; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sohmer, H Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, POB 12272, IL-91120Jerusalem, Israel Hebrew Univ Jerusalem POB 12272 Jerusalem Israel IL-91120 srael
Citazione:
R. Fraenkel et al., "The effect of various durations of noise exposure on auditory brainstem response, distortion product otoacoustic emissions and transient evoked otoacoustic emissions in rats", AUDIOL NEUR, 6(1), 2001, pp. 40-49

Abstract

This study was designed to investigate the effect of various durations of noise exposure in animals on physiological responses from the cochlea whichare also used clinically in humans: auditory brainstem response (ABR), transient evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs). Rats were exposed to 113 dB SPL broad-band noise (12 h on/12 h off) for durations of 3, 6, 9, 12, 15 and 21 days, and tested 24 h after cessation of the noise and again after a period of 6 weeks. ABR threshold to click stimuli and to a 2-kHz tone burst (TB), TEOAE energy content and DPOAE amplitude in the exposed rats were compared to those in a group of control rats not exposed to noise. ABR thresholds (click and TB) were significantly elevated in all exposure duration groups compared to control rats. DPOAE amplitudes and TEOAE energy content were significantly reduced. The mean ABR thresholds following 21 days exposure were significantly greater (click = 100 dB pe SPL; TB = 115 dB pe SPL) than those following 3 days exposure (click = 86 dB pe SPL; TB = 91 dB pe SPL). Linear regression analysis between recorded responses and duration of noise exposure (days) showed a significant increase in ABR thresholds of approximately 0.8-1.4 dB/day. TEOAE and DPOAE responses showed no such dependence on noise duration and were already maximally reduced after only 3 days of exposure. This can beexplained by the possibility that short noise exposures may cause damage to the early, more active stages of cochlear transduction (as shown by TEOAEs and DPOAEs). As the noise exposure continues, further damage may be induced at additional, later stages of the cochlear transduction cascade (as shown by ABR). Thus, ABR seems more sensitive to noise duration than OAE measures. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 20/02/20 alle ore 03:14:27