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Titolo:
On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice
Autore:
Dekundy, A; Blaszczak, P; Kaminski, R; Turski, WA;
Indirizzi:
Inst Agr Med, Dept Toxicol, PL-20950 Lublin, Poland Inst Agr Med Lublin Poland PL-20950 ept Toxicol, PL-20950 Lublin, Poland Med Univ, Dept Pharmacol & Toxicol, PL-20090 Lublin, Poland Med Univ Lublin Poland PL-20090 macol & Toxicol, PL-20090 Lublin, Poland
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 11, volume: 74, anno: 2001,
pagine: 702 - 708
SICI:
0340-5761(200101)74:11<702:OTIBAA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMAN-INDUCED SEIZURES; METHYL-D-ASPARTATE; ORGANO-PHOSPHATE; RAT HIPPOCAMPUS; BRAIN-DAMAGE; CARBAMATE; MEMANTINE; MK-801; ANTICONVULSANT; EPILEPSY;
Keywords:
organophosphate; carbamate; NMDA antagonist; atropine; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Turski, WA Inst Agr Med, Dept Toxicol, Jaczewskiego 2, PL-20950 Lublin, Poland Inst Agr Med Jaczewskiego 2 Lublin Poland PL-20950 lin, Poland
Citazione:
A. Dekundy et al., "On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice", ARCH TOXIC, 74(11), 2001, pp. 702-708

Abstract

Both organophosphate (OP) and carbamate pesticides may produce seizures and death commonly attributed to the inhibition of acetylcholinesterase (AChE) and subsequent excess of acetylcholine (ACh). The anticonvulsant and neuroprotective properties of N-methyl-D-aspartate (NMDA) receptor antagonists in animals encouraged us to investigate their effects on the toxic and convulsant properties of OP and carbamate pesticides. Adult Swiss mice were systemically injected with the OP pesticide, chlorfenvinphos (CVP), or the carbamate pesticide, methomyl (MET). Both CVP and MET induced dose-dependent seizure activity and death in mice. Pretreatment with the muscarinic antagonist, atropine (ATR), at a dose of 1.8 mg/kg did not prevent seizures but decreased the lethal effects of CVP and MET. Pretreatment with the NMDA antagonists, dizocilpine (MK-801) at a dose of 1 mg/kg or 3-((R,S)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) at a dose of 10 mg/kg, influenced neither MET-induced seizures nor CVP- or MET-induced death. However, bothMK-801 and CPP blocked CVP-induced seizures. Concurrent administration of ATR and the NMDA antagonists prevented seizures produced by CVP, but not those produced by MET. Nevertheless, both MK-801 and CPP coadministered with ATR markedly enhanced its antilethal effects in CVP- and MET-intoxicated mice. The antidotes had no influence upon brain AChE activities in mice treated with saline or CVP or MET. It seems that combined treatment with ATR andNMDA receptor antagonists might be of clinical relevance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:50:13