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Titolo:
Natural history of cardiovascular manifestations in Marfan syndrome
Autore:
van Karnebeek, CDM; Naeff, MSJ; Mulder, BJM; Hennekam, RCM; Offringa, M;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, Dept Paediat H3 150, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
ARCHIVES OF DISEASE IN CHILDHOOD
fascicolo: 2, volume: 84, anno: 2001,
pagine: 129 - 137
SICI:
0003-9888(200102)84:2<129:NHOCMI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITRAL-VALVE PROLAPSE; LIFE EXPECTANCY; CHILDREN; FIBRILLIN; GENE; ABNORMALITIES; CHROMOSOME-15; DIMENSIONS; CHILDHOOD; CRITERIA;
Keywords:
Marfan syndrome; cohort study; mitral valve; aorta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Offringa, M Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, Dept Paediat H3 150, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
C.D.M. van Karnebeek et al., "Natural history of cardiovascular manifestations in Marfan syndrome", ARCH DIS CH, 84(2), 2001, pp. 129-137

Abstract

Aims-To investigate the natural history of mitral valve and aortic abnormalities in patients with Marfan syndrome during childhood and adolescence. Methods-Fifty two patients with Marfan syndrome were followed for a mean of 7.9 years. Occurrence of adverse cardiovascular outcomes was measured clinically and by ultrasound examination. Results-Mitral valve prolapse (MVP) was diagnosed in 46 patients at a meanage of 9.7 years, more than 80% of whom presented as "silent MVP". Mitral regurgitation (MR) occurred in 25 patients, aortic dilatation in 43, and aortic regurgitation (AR) in 13. Both MVP and aortic dilatation developed at a constant rate during the age period 5-20 years. In 23 patients MVP was diagnosed before aortic dilatation, in 18 the reverse occurred, and In 11 patients the two abnormalities were diagnosed simultaneously. During follow up, 21 patients showed progression of mitral valve dysfunction; progression of aortic abnormalities occurred in 13. Aortic surgery was performed in 10; two died of subsequent complications. Mitral valve surgery was performed insix. In sporadic female Marfan patients the age at initial diagnosis of MVP, MR, aortic dilatation, and AR was lowest, the grade of MR and AR most severe, the time lapse between the occurrence of MVP and subsequent MR as well as between dilatation and subsequent AR shortest, and the risk for cardiovascular associated morbidity and mortality highest. Conclusions-During childhood and adolescence in Marfan syndrome, mitral valve dysfunction as well as aortic abnormalities develop and progress gradually, often without symptoms, but may cause considerable morbidity and mortality by the end of the second decade, especially in female sporadic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:21:18