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Titolo:
Antitumour effect of L-2,4 diaminobutyric acid on a hepatoma cell line
Autore:
Blind, PJ; Waldenstrom, A; Berggren, D; Ronquist, G;
Indirizzi:
Univ Uppsala Hosp, Dept Clin Chem, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 n Chem, S-75185 Uppsala, Sweden Umea Univ, Dept Surg, Umea, Sweden Umea Univ Umea SwedenUmea Univ, Dept Surg, Umea, Sweden Umea Univ, Dept Internal Med, Umea, Sweden Umea Univ Umea SwedenUmea Univ, Dept Internal Med, Umea, Sweden Umea Univ, Dept Otorhinolaryngol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 ept Otorhinolaryngol, S-90187 Umea, Sweden
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 6B, volume: 20, anno: 2000,
pagine: 4275 - 4278
SICI:
0250-7005(200011/12)20:6B<4275:AEOLDA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR;
Keywords:
antitumour effect; diaminobutyric acid; hepatoma cells; cancer cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Ronquist, G Univ Uppsala Hosp, Dept Clin Chem, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 185 Uppsala, Sweden
Citazione:
P.J. Blind et al., "Antitumour effect of L-2,4 diaminobutyric acid on a hepatoma cell line", ANTICANC R, 20(6B), 2000, pp. 4275-4278

Abstract

Pharmacological treatment of malignant disease is often insufficient highlighting the need for mon efficient treatment based on new principles. We have observed that the amino acid analogue diaminobutyric acid (DAB), accumulates in malignant cells apparently without saturation kinetics, leading to hyperosmosis and subsequently to cell lysis. In the first in vitro part of the present study hepatoma cells wets incubated with DAB in miniwells in the presence or absence of physiological amino acids. In the in vivo part malignant cells were inoculated into Int liver after laparotomy. The tumour was treated by continuous infusion of DAB via a catheter; the tip of which was placed in the center of the tumour: DAB had a significant antitumour effect both in vitro and in vivo. The principle of action of DAB as an antitumour agent is unique and therefore would be the ideal partner to practically any other cytostatic drug for a combined treatment to achieve a synergisticeffect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:38:43