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Titolo:
Reactive oxygen and nitrogen species: Efficient, selective, and interactive signals during intercellular induction of apoptosis
Autore:
Bauer, G;
Indirizzi:
Univ Freiburg, Inst Med Mikrobiol & Hyg, Abt Virol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 Virol, D-79104 Freiburg, Germany
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 6B, volume: 20, anno: 2000,
pagine: 4115 - 4139
SICI:
0250-7005(200011/12)20:6B<4115:ROANSE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEROXYNITRITE-MEDIATED OXIDATIONS; HYDROXYL RADICAL PRODUCTION; GENERATED SINGLET OXYGEN; BETA-INDUCED ELIMINATION; BENZOIC-ACID HYDRAZIDES; LOW-DENSITY-LIPOPROTEIN; TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-BETA; NITRIC-OXIDE; TRANSFORMED-CELLS;
Keywords:
reactive oxygen species; reactive nitrogen species; apoptosis; intercellular signalling; oncogenesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
173
Recensione:
Indirizzi per estratti:
Indirizzo: Bauer, G Univ Freiburg, Inst Med Mikrobiol & Hyg, Abt Virol, Hermann Herder Str 11,D-79104 Freiburg, Germany Univ Freiburg Hermann Herder Str 11 Freiburg Germany D-79104 any
Citazione:
G. Bauer, "Reactive oxygen and nitrogen species: Efficient, selective, and interactive signals during intercellular induction of apoptosis", ANTICANC R, 20(6B), 2000, pp. 4115-4139

Abstract

During intercellular induction of apoptosis, transformed fibroblasts are specifically eliminated by their nontransformed neighbours. This potential control step of oncogenesis is based on a sophisticated system of interdependencies and interactions of reactive oxygen and nitrogen species. Activatednontransformed effector cells release a novel peroxidase and nitric oxide. Superoxide anions generated extracellularly by transformed cells participate in intercellular signalling and also determine transformed cells as selective tar-gets for intel cellular induction of apoptosis. The interaction of these molecules results in two major signalling pathways, which are basedon HOCl/hydroxyl radicals and on NO/ peroxynitrite. In addition, involvement of nitrylchloride seems to be conceivable in an alternative pathway. Hydrogenperoxide plays a central and ambivalent role by fostering the HOCl/hydroxyl radical pathway and by inhibiting the NO/peroxynitrite pathway. The interaction of ROS and RNS during intercellular induction of apoptosis seemsto represent a general signalling concept utilized by several natural antitumor systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:24:43