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Titolo:
Malignant gastrointestinal stromal tumors of the small intestine: A reviewof 50 cases from a prospective database
Autore:
Crosby, JA; Catton, CN; Davis, A; Couture, J; OSullivan, B; Kandel, R; Swallow, CJ;
Indirizzi:
Mt Sinai Hosp, Musculoskeletal Oncol Unit, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Unit, Toronto, ON M5G 1X5, Canada Univ Toronto, Sarcoma Grp, Toronto, ON, Canada Univ Toronto Toronto ON Canada Toronto, Sarcoma Grp, Toronto, ON, Canada Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada Mt SinaiHosp Toronto ON Canada M5G 1X5 Med, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp, Dept Surg, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Surg, Toronto, ON M5G 1X5, Canada Univ Toronto, Toronto, ON, Canada Univ Toronto Toronto ON CanadaUniv Toronto, Toronto, ON, Canada Princess Margaret Hosp, Dept Radiat Oncol, Toronto, ON M4X 1K9, Canada Princess Margaret Hosp Toronto ON Canada M4X 1K9 onto, ON M4X 1K9, Canada Princess Margaret Hosp, Dept Surg Oncol, Toronto, ON M4X 1K9, Canada Princess Margaret Hosp Toronto ON Canada M4X 1K9 onto, ON M4X 1K9, Canada
Titolo Testata:
ANNALS OF SURGICAL ONCOLOGY
fascicolo: 1, volume: 8, anno: 2001,
pagine: 50 - 59
SICI:
1068-9265(200101/02)8:1<50:MGSTOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE TUMORS; SOFT-TISSUE SARCOMAS; PACEMAKER CELL TUMOR; C-KIT; PROGNOSTIC FACTORS; INTERSTITIAL-CELLS; TRACT; LEIOMYOSARCOMAS; MUTATIONS; CAJAL;
Keywords:
GIST; gastrointestinal stromal tumors; intestinal sarcoma; small intestinal neoplasms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Swallow, CJ Mt Sinai Hosp, Musculoskeletal Oncol Unit, Room 1224,600 Univ Ave, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Room 1224,600 Univ Ave Toronto ON Canada M5G 1X5
Citazione:
J.A. Crosby et al., "Malignant gastrointestinal stromal tumors of the small intestine: A reviewof 50 cases from a prospective database", ANN SURG O, 8(1), 2001, pp. 50-59

Abstract

Background: Malignant gastrointestinal stromal tumors (M-GIST) are rare mesenchymal tumors originating in the wall of the gastrointestinal (GI) tract. Previous studies have included Limited numbers of patients, and most included malignant and benign cases from throughout the GI tract. We reviewed the experience of a single tertiary cancer care center with M-GIST of the small intestine only. Methods: A prospective database identified all patientsseen from 1989 to 1998. Clinical and pathological data, treatment, and outcome were analyzed. Overall median follow-up time was 24 months (range, 1-176 months). Results: Fifty patients (31 male, 19 female) were identified. Mean age at diagnosis was 55 years. Disease was localized in 11 patients, locally advanced (invasion into adjacent organs/peritoneum) in 24 patients, perforated in 4 patients, multiple primary lesions in 2, patients, and distant metastases in 9 patients. All patients underwent resection, which was complete in 70%. Locoregional recurrence (LR) developed in 43% (median, 25 months), and distant metastases in 59% (median, 31 months) of patients at risk. At last follow-up, 14 patients were alive (6 disease-free), 2 had died disease-free, and 34 died with recurrent disease. Overall survival (OS) was similar forlocalized and locally advanced disease; OS also was similar for patients with multiple primaries and distant metastases at diagnosis. Patients were grouped into three stages: (I) patients with localized and locally advanced disease; (II) patients with perforated; and ( III) patients with multiple primaries and distant metastases. Actuarial OS at 5 years was 41% (n = 50)-42% for those with complete resection and 8% for incomplete resection. Univariable analysis showed that earlier stage at diagnosis (P = .001) and completeness of resection (P = .004) predicted for longer OS. Conclusions: Most patients with M-GIST of the small intestine relapse following resection, but survival may be prolonged. In univariable analysis, stage at presentation and complete resection were significant prognostic variables for OS; grade was not significant. Localized and locally advanced M-GIST of the small intestine have a mean OS > 5 years. Complete resection should be the goal of initial surgical treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:36:41