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Titolo:
High-density lipoprotein: gene-based approaches to the prevention of atherosclerosis
Autore:
Rong, JX; Fisher, EA;
Indirizzi:
CUNY Mt Sinai Sch Med, Zena & Michael Wiener Cardiovasc Inst, Dept Med, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 t Med, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Zena & Michael Wiener Cardiovasc Inst, Lab LipoprotRes, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 otRes, New York, NY 10029 USA
Titolo Testata:
ANNALS OF MEDICINE
fascicolo: 9, volume: 32, anno: 2000,
pagine: 642 - 651
SICI:
0785-3890(200012)32:9<642:HLGATT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-I; CHOLESTERYL-ESTER TRANSFER; CORONARY HEART-DISEASE; PHOSPHOLIPID TRANSFER PROTEIN; BINDING CASSETTE TRANSPORTER-1; ADENOVIRUS-MEDIATED TRANSFER; APOE-DEFICIENT MICE; RECEPTOR SR-BI; KNOCK-OUT MICE; TRANSGENIC MICE;
Keywords:
atherosclerosis; gene therapy; high-density lipoprotein metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Fisher, EA CUNY Mt Sinai Sch Med, Zena & Michael Wiener Cardiovasc Inst, Dept Med, 1 Gustave L Levy Pl,Box 1269, New York, NY 10029 USA CUNY Mt SinaiSch Med 1 Gustave L Levy Pl,Box 1269 New York NY USA 10029
Citazione:
J.X. Rong e E.A. Fisher, "High-density lipoprotein: gene-based approaches to the prevention of atherosclerosis", ANN MED, 32(9), 2000, pp. 642-651

Abstract

Although the atheroprotective role of high-density lipoprotein (HDL) has been well documented in epidemiological and animal studies, highly effectivetherapeutic approaches for the selective increase of plasma HDL levels or function are not yet available. Several mechanisms by which HDL exerts an atheroprotective effect have been proposed on the basis of experiments in vitro and in vivo. These mechanisms include directing excess cellular cholesterol from the peripheral tissues to the liver in 'reverse cholesterol transport', inhibiting oxidative modification or aggregation of LDL, and modulating inflammatory responses to favour vasoprotection. This review gives an overview of the genes regulating these mechanisms, such as those encoding apolipoprotein AT, lecithin:cholesterol acyltransferase (LCAT), scavenger receptor B1 (SR-BI), and the ATP-binding cassette transporter 1 (ABC1), and the potential to exploit them to develop gene-based therapeutic approaches toincrease the level or function of HDL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:57:24