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Titolo:
Hyperhomocysteinaemia and atherothrombosis
Autore:
Cattaneo, M;
Indirizzi:
Univ Milan, Osped Maggiore, IRCCS,Dept Internal Med, Angelo Bianchi BonomiHemophilia & Thrombosis Ctr, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 ia & Thrombosis Ctr, I-20122 Milan, Italy
Titolo Testata:
ANNALS OF MEDICINE
, volume: 32, anno: 2000, supplemento:, 1
pagine: 46 - 52
SICI:
0785-3890(200012)32:<46:HAA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA TOTAL HOMOCYSTEINE; CORONARY HEART-DISEASE; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; SERUM TOTAL HOMOCYSTEINE; RISK FACTOR; VASCULAR-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; COMMON MUTATION; ELDERLY MEN;
Keywords:
atherosclerosis; cerebrovascular disease; coronary artery disease; homocysteine; peripheral artery disease; risk factors; thrombosis; venous thromboembolism; vitamins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Cattaneo, M Via Pace 9, I-20122 Milan, Italy Via Pace 9 Milan Italy I-20122 Pace 9, I-20122 Milan, Italy
Citazione:
M. Cattaneo, "Hyperhomocysteinaemia and atherothrombosis", ANN MED, 32, 2000, pp. 46-52

Abstract

Homocysteine (Hcy) is a sulfhydryl amino acid derived from the metabolic conversion of methionine that is dependent on vitamins (folic acid, B-12 andB-6) as cofactors or cosubstrates. In 1969, McCully first reported the presence of severe atherosclerotic lesions in patients with severe hyperhomocysteinaemia and hypothesized the existence of a pathogenic link between hyperhomocysteinaemia and atherogenesis. Several case-control and cross-sectional studies confirmed the initial hypothesis of McCully, showing that also moderate hyperhomocysteinaemia is associated with a heightened risk of occlusive arterial disease. Less consistent results have been reported by prospective cohort studies of subjects who were healthy at the time of their enrollment, whereas prospective cohort studies of patients with overt coronary artery disease or other risk conditions consistently confirmed the association between moderate hyperhomocysteinaemia and the risk of cardiovascular morbidity and mortality. More recently, an association between moderate hyperhomocysteinaemia and heightened risk of venous thromboembolism has been documented, suggesting that hyperhomocysteinaemia might be involved not only in atherogenesis, but also in thrombogenesis. The mechanisms by which hyperhomocysteinaemia might contribute to atherogenesis and thrombogenesis are incompletely understood. The mainstay of treatment of hyperhomocysteinaemia is folic acid, alone or in combination with vitamins B-12 and B-6. Althoughit is quite clear that vitamins effectively reduce the plasma levels of total Hcy, we do not yet know whether they will decrease the risk of vasculardisease. The results of ongoing randomized, placebo-controlled, double-blinded trials on the effects of vitamins on thrombotic risk will help in defining whether the relationship between hyperhomocysteinaemia and thrombosis is causal, and will potentially have a dramatic impact on the prevention ofthromboembolic events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:35:30