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Titolo:
Cardiovascular disease and mortality in older adults with small abdominal aortic aneurysms detected by ultrasonography: The cardiovascular health study
Autore:
Newman, AB; Arnold, AM; Burke, GL; OLeary, DH; Manolio, TA;
Indirizzi:
Univ Pittsburgh, Sch Med, Div Geriatr Med, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 atr Med, Pittsburgh, PA 15213 USA Univ Washington, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iv Washington, Seattle, WA 98195 USA Wake Forest Univ, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Tufts New England Med Ctr, Boston, MA USA Tufts New England Med Ctr Boston MA USA England Med Ctr, Boston, MA USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA
Titolo Testata:
ANNALS OF INTERNAL MEDICINE
fascicolo: 3, volume: 134, anno: 2001,
pagine: 182 - 190
SICI:
0003-4819(20010206)134:3<182:CDAMIO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISK-FACTORS; PREVALENCE; ATHEROSCLEROSIS; SURVEILLANCE; RUPTURE; FATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Newman, AB Univ Pittsburgh, Sch Med, Div Geriatr Med, 3520 5th Ave,Suite 300, Pittsburgh, PA 15213 USA Univ Pittsburgh 3520 5th Ave,Suite 300 Pittsburgh PA USA 15213
Citazione:
A.B. Newman et al., "Cardiovascular disease and mortality in older adults with small abdominal aortic aneurysms detected by ultrasonography: The cardiovascular health study", ANN INT MED, 134(3), 2001, pp. 182-190

Abstract

Background: Persons with abdominal aortic aneurysm are more likely to havea higher prevalence of risk factors for and clinical manifestations of cardiovascular disease. It is unknown whether these factors explain the high mortality rate associated with abdominal aortic aneurysm. Objective: To describe the risk for mortality, cardiovascular mortality, and cardiovascular morbidity in persons screened for abdominal aortic aneurysm. Design: Longitudinal cohort study. Setting: Four communities in the United States. Participants: 4734 men and women older than 65 years of age recruited fromMedicare eligibility lists. Measurements: Abdominal ultrasonography was used to measure the aortic diameter and the ratio of infrarenal to suprarenal measurement of aortic diameter in 1992-1993. Abdominal aortic aneurysm was defined as aortic diameter of 3 cm or greater or infrarenal-to-suprarenal ratio of 1.2 or greater. Mortality, cardiovascular disease mortality, incident cardiovascular disease, and repair or rupture were assessed after 4.5 years. Results: The prevalence of aneurysm was 8.8%, and 87.7% of aneurysms were 3.5 cm or less in diameter, Rates of total mortality (65.1 vs. 32.8 per 1000 person-years), cardiovascular mortality (34.3 vs. 13.8 per 1000 person-years), and incident cardiovascular disease (47.3 vs. 31.0 per 1000 person-years) were higher in participants with aneurysm than in those without aneurysm; after adjustment for age, risk factors, and presence of other cardiovascular disease, the respective relative risks were 1.32, 1.36, and 1.57. Rates of repair and rupture were low. Conclusions: Rates of total mortality, cardiovascular disease mortality, and incident cardiovascular disease were higher in participants with abdominal aortic aneurysm than in those without aneurysm, independent of age, sex,other clinical cardiovascular disease, and extent of atherosclerosis detected by noninvasive testing. Persons with smaller aneurysms detected by ultrasonography should be advised to modify risk factors for cardiovascular disease while under surveillance for increase in the size of the aneurysm.

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Documento generato il 25/11/20 alle ore 04:36:40