Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A parametric approach to measuring cerebral blood flow autoregulation fromspontaneous variations in blood pressure
Autore:
Simpson, DM; Panerai, RB; Evans, DH; Naylor, AR;
Indirizzi:
Univ Leicester, Fac Med, Div Med Phys, Leicester LE1 5WW, Leics, England Univ Leicester Leicester Leics England LE1 5WW er LE1 5WW, Leics, England Univ Leicester, Fac Med, Dept Surg, Leicester LE1 5WW, Leics, England UnivLeicester Leicester Leics England LE1 5WW er LE1 5WW, Leics, England
Titolo Testata:
ANNALS OF BIOMEDICAL ENGINEERING
fascicolo: 1, volume: 29, anno: 2001,
pagine: 18 - 25
SICI:
0090-6964(200101)29:1<18:APATMC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREQUENCY-DOMAIN ANALYSIS; SPONTANEOUS FLUCTUATIONS; DYNAMIC AUTOREGULATION; AUTO-REGULATION; CARBON-DIOXIDE; VELOCITY; HUMANS; REACTIVITY; STENOSIS; CO2;
Keywords:
cerebral hemodynamics; transcranial Doppler ultrasound; signal processing; wiener filter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Simpson, DM Leicester Royal Infirm, Dept Phys Med, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WW ngland
Citazione:
D.M. Simpson et al., "A parametric approach to measuring cerebral blood flow autoregulation fromspontaneous variations in blood pressure", ANN BIOMED, 29(1), 2001, pp. 18-25

Abstract

Autoregulation maintains cerebral blood flow (CBF) almost constant in the face of changes in arterial blood pressure (ABP). Tests for impairment of this process using only spontaneous fluctuations in ABP, without provoking large variations, are of great clinical interest, and a range of different approaches have previously been applied. Extending earlier work based on linear filters, we propose a simple parametric method using a first order finite impulse response filter. We evaluate-the method on ABP and CBF velocity [(CBFV), from trancranial Doppler ultrasound] signals collected in 60 patients with stenosis or occlusion of the carotid arteries. Data were collectedduring the inspiration of ambient air, a 5% CO2/air mixture, and finally the return to ambient air. Equivalent data were collected in 15 normal subjects. The filters estimated from the data segments with constant inspiratorypCO2 showed the expected high-pass characteristic, which was reduced during hypercapnia and also in patients. Highly significant correlation between the filter parameters and cerebrovascular reactivity (percent increase in CBFV per unit change in end-tidal pCO2) gives further evidence that the filters reflect autoregulation. The method allows simple parametrization of thedynamic autoregulatory responses in CBFV, and the analysis of short (1 min) data segments. (C) 2001 Biomedical Engineering Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:56:54