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Titolo:
Xenon inhibits but N2O enhances ketamine-induced c-fos expression in the rat posterior cingulate and retrosplenial cortices
Autore:
Nagata, A; Nakao, S; Nishizawa, N; Masuzawa, M; Inada, T; Murao, K; Miyamoto, E; Shingu, K;
Indirizzi:
Kansai Med Univ, Dept Anesthesiol, Moriguchi, Osaka 5708507, Japan Kansai Med Univ Moriguchi Osaka Japan 5708507 guchi, Osaka 5708507, Japan
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 2, volume: 92, anno: 2001,
pagine: 362 - 368
SICI:
0003-2999(200102)92:2<362:XIBNEK>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA ANTAGONIST; BRAIN REGIONS; PHENCYCLIDINE; ANESTHESIA; GENE; INDUCTION; ANTISENSE; NEURONS; DAMAGE; MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Nakao, S Kansai Med Univ, Dept Anesthesiol, Moriguchi, Osaka 5708507, Japan Kansai Med Univ Moriguchi Osaka Japan 5708507 aka 5708507, Japan
Citazione:
A. Nagata et al., "Xenon inhibits but N2O enhances ketamine-induced c-fos expression in the rat posterior cingulate and retrosplenial cortices", ANESTH ANAL, 92(2), 2001, pp. 362-368

Abstract

Both nitrous oxide (N2O) and xenon are N-methyl-D-aspartate receptor antagonists that have psychotomimetic effects and cause neuronal injuries in theposterior cingulate and retrosplenial cortices. We investigated the effectof xenon, xenon with ketamine, N2O, and N2O with ketamine on c-Fos expression in the rat posterior cingulate and retrosplenial cortices, a marker of psychotomimetic effects. Brain sections were prepared, and c-Fos expressionwas detected with immunohistochemical methods. A loss of microtubule-associated protein 2, a marker of neuronal injury, was also investigated. The number of Fos-like immunoreactivity positive cells by ketamine IV at a dose of 5 mg/kg under 70% N2O (128 +/- 12 cells per 0.5 mm(2)) was significantly more than those under 30% (15 +/- 2 cells per 0.5 mm(2)) and 70% xenon (2 +/- 1 cells per 0.5 mm(2)). Despite differences in c-fos immunoreactivity, there was no loss of microtubule-associated protein 2 immunoreactivity in any group examined. Xenon may suppress the adverse neuronal effects of ketamine, and combined use of xenon and ketamine seems to be safe in respect to neuronal adverse effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:40:03