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Titolo:
Sinonasal undifferentiated carcinoma - Immunohistochemical profile and lack of EBV association
Autore:
Cerilli, LA; Holst, VA; Brandwein, MS; Stoler, MH; Mills, SE;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Surg Pathol, Old Med Sch,Robert E Fechner Lab Surg Pathol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Mt Sinai Sch Med, New York, NY USA Mt Sinai Sch Med New York NY USAMt Sinai Sch Med, New York, NY USA
Titolo Testata:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 156 - 163
SICI:
0147-5185(200102)25:2<156:SUC-IP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; IN-SITU HYBRIDIZATION; TUMORS; EXPERIENCE; DIAGNOSIS; NEOPLASM; SARCOMA; PROTEIN; MARKER;
Keywords:
Epstein-Barr virus; lymphoepithelioma undifferentiated carcinoma; immunohistochemistry; carcinoembryonic antigen; p53; EBER-1; CD99; epithelial membrane antigen; neuron-specific enolase; chromogranin, synaptophysin; placental alkaline phosphatase; LMP-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Cerilli, LA Univ Virginia, Hlth Sci Ctr, Dept Surg Pathol, Old Med Sch,Robert E Fechner Lab Surg Pathol, Box 800214,Jefferson Pk Blvd, Charlottesville, VA 22908 USA Univ Virginia Box 800214,Jefferson Pk Blvd Charlottesville VA USA 22908
Citazione:
L.A. Cerilli et al., "Sinonasal undifferentiated carcinoma - Immunohistochemical profile and lack of EBV association", AM J SURG P, 25(2), 2001, pp. 156-163

Abstract

The role of Epstein-Barr virus (EBV) in the development of sinonasal undifferentiated carcinoma (SNUC) remains unresolved. Reports of EBV-positivity in SNUG may reflect inclusion of lymphoepithelioma-like carcinomas within this group. In addition, SNUG have been incompletely characterized immunohistochemically, and their undifferentiated appearance often requires such ancillary studies to aid in their distinction from other high-grade neoplasms. To address these two issues, 25 cases of SNUG diagnosed between the years 1983 and 1999 were selected from our files. EBER in situ hybridization (ISH) was performed on the paraffin-embedded tissue by using H-3-labeled EBER-1RNA probes. Neoplasms with sufficient tissue (22 of 25) were evaluated immunohistochemically for Ki-67, p53, chromogranin, synaptophysin, placental alkaline phosphatase (PLAP). CD99, carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), neuron-specific enolase (NSE), and latent membrane protein-1 (LMP-1). The median patient age was 58 years (range, 20-81 years), with a male-to-female ratio of approximately 3:1. The most common tumorlocation was the nasal cavity (18 cases), followed by the ethmoid and maxillary sinuses. Median survival was 18 months. All 25 tumors were negative for EBER-1 by ISH. Ki-67 was negative in one case. 1+ in nine, 2+ in six, 3in five, and 4+ in one. P53 was negative in nine, 1+ in five, 2+ in two, 3 in none, and 4+ in six. CD99 expression was strongly positive in 3 of 22 (14%) and completely negative in the remainder. Variably intense focal staining for EMA was present in 4 of 22 (18%). NSE faintly stained 4 of 22 (18%). Chromogranin, synaptophysin, FLAP, CEA, and LMP-I were negative (0 of 22). Our results suggest that EBV does not play a role in the development of SNUG. Strict histologic criteria are necessary to avoid confusion with lymphoepithelioma-like carcinoma or other high-grade malignancies in this region. The finding of occasional CD99-positive cases adds SNUC to the growing list of CD99-positive neoplasms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:11:34