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Titolo:
Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentallyinduced placental insufficiency
Autore:
Nicholls, T; Lacey, B; Nitsos, I; Smythe, G; Walker, DW;
Indirizzi:
Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 siol, Clayton, Vic 3168, Australia Univ New S Wales, Ray Williams Biomed Mass Spect Fac, Kensington, NSW 2033, Australia Univ New S Wales Kensington NSW Australia 2033 ngton, NSW 2033, Australia
Titolo Testata:
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
fascicolo: 2, volume: 184, anno: 2001,
pagine: 203 - 208
SICI:
0002-9378(200101)184:2<203:RCIKAQ>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; ASTROCYTES; INJURY; ENCEPHALOPATHY; EMBOLIZATION; ANTAGONIST; METABOLITE; INCREASES; RECEPTOR; FETUS;
Keywords:
fetal sheep; placental compromise; brain; glial fibrillary acidic protein; kynurenic acid; quinolinic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, DW Monash Univ, Dept Physiol, Wellington Rd, Clayton, Vic 3168, Australia Monash Univ Wellington Rd Clayton Vic Australia 3168 Australia
Citazione:
T. Nicholls et al., "Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentallyinduced placental insufficiency", AM J OBST G, 184(2), 2001, pp. 203-208

Abstract

OBJECTIVE: This study was undertaken to examine the effects of chronic embolization of the umbilical circulation during late gestation on regional concentrations of quinolinic acid and kynurenic acid (neuroactive products oftryptophan catabolism) and of the astrocyte-associated glial fibrillary acidic protein in the fetal brain. STUDY DESIGN: Pregnant ewes bearing fetuses with long-term catheter placement were treated daily with injections of either saline solution (n = 4; control group) or mucopolysaccharide microspheres (n = 5; embolized group) into the umbilical circulation through a femoral artery catheter between 120 and 140 days' gestation. The fetuses in the embolized group received sufficient microspheres each day to reduce and maintain the femoral arterial Po-2at less than or equal to 12 mm Hg. Autopsies were performed at 140 days' gestation to obtain the fetal brain for chemical analysis. RESULTS: Umbilical embolization resulted in nonacidemic hypoxia and hypoglycemia at 140 days' gestation. Quinolinic acid concentrations in the embolized group were significantly increased in the medulla, pens, midbrain, hypothalamus, and hippocampus, whereas kynurenic acid concentrations in the embolized group were reduced in the hippocampus and hypothalamus. There were significant reductions in glial fibrillary acidic protein contents in the occipitoparietal cortex, hippocampus, and pens in the embolized group. CONCLUSION: Placental compromise during late pregnancy had effects on kynurenine metabolism and astrocyte function in some regions of the fetal sheepbrain. We suggest that these changes increase the vulnerability of the brain to asphyxial injury during late gestation and the perinatal period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 12:50:26