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Titolo:
Elevation in erythroblast count in maternal blood before the onset of preeclampsia
Autore:
Holzgreve, W; Li, JC; Steinborn, A; Kulz, T; Sohn, C; Hodel, M; Hahn, S;
Indirizzi:
Univ Basel, Dept Obstet & Gynecol, CH-4031 Basel, Switzerland Univ Basel Basel Switzerland CH-4031 Gynecol, CH-4031 Basel, Switzerland Univ Frankfurt, Dept Obstet & Gynecol, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 necol, D-6000 Frankfurt, Germany Univ Rostock, Dept Obstet & Gynecol, D-2500 Rostock, Germany Univ RostockRostock Germany D-2500 t & Gynecol, D-2500 Rostock, Germany
Titolo Testata:
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
fascicolo: 2, volume: 184, anno: 2001,
pagine: 165 - 168
SICI:
0002-9378(200101)184:2<165:EIECIM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL CELLS; CIRCULATION; DIAGNOSIS; GRADIENT;
Keywords:
erythroblasts; fetal cell traffic; preeclampsia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Holzgreve, W Univ Basel, Dept Obstet & Gynecol, Schanzenstr 46, CH-4031 Basel, Switzerland Univ Basel Schanzenstr 46 Basel Switzerland CH-4031 tzerland
Citazione:
W. Holzgreve et al., "Elevation in erythroblast count in maternal blood before the onset of preeclampsia", AM J OBST G, 184(2), 2001, pp. 165-168

Abstract

OBJECTIVE: We recently showed that both maternal and fetal erythroblast counts are elevated in the peripheral blood of pregnant women with preeclampsia. The purpose of this study was to examine whether this elevation actually occurs before the clinical onset of the disorder. STUDY DESIGN: Erythroblasts were enriched and enumerated in 97 maternal blood samples obtained in the second trimester, and results were subsequentlycorrelated with pregnancy outcomes. RESULTS: Significantly higher quantities of erythroblasts (mean, 6041.7 vs928.9; P = .008) were detected in blood samples obtained from women who later acquired preeclampsia (n = 15) than in blood samples from the control cohort (n = 72). Intrauterine growth restriction (n = 10) was not accompanied by a similar rise in erythroblast count. CONCLUSION: Because a large proportion of the erythroblasts in maternal blood are fetal, our data suggest that fetal-maternal cell traffic is affected early in pregnancies that are later complicated by preeclampsia but not in those affected only by intrauterine growth restriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:39:16