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Titolo:
Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate NF-KB activity and interleukin-2 gene expression
Autore:
Merlo, JJ; Tsygankov, AY;
Indirizzi:
Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USATemple Univ Philadelphia PA USA 19140 Immunol, Philadelphia, PA 19140 USA
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 279, anno: 2001,
pagine: 325 - 338
SICI:
0042-6822(20010105)279:1<325:HSOTAS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN T-CELLS; IMMEDIATE-EARLY GENE; MEDIATED SIGNAL-TRANSDUCTION; TYROSINE KINASE PYK2; HUMAN LYMPHOCYTES-T; SUBGROUP-C STRAINS; 3 DNA SUBGROUPS; TRANSCRIPTION FACTORS; FUNCTIONAL PHENOTYPE; DOWN-REGULATION;
Keywords:
Herpesvirus saimiri; Tip; StpC; protein tyrosine kinases; interleukin-2; transcription; NF-kappa B; NF-AT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Tsygankov, AY Temple Univ, Sch Med, Dept Microbiol & Immunol, 3400 N BroadSt,Kresge Bldg,Rm 506, Philadelphia, PA 19140 USA Temple Univ 3400 N BroadSt,Kresge Bldg,Rm 506 Philadelphia PA USA 19140
Citazione:
J.J. Merlo e A.Y. Tsygankov, "Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate NF-KB activity and interleukin-2 gene expression", VIROLOGY, 279(1), 2001, pp. 325-338

Abstract

Saimiriine herpesvirus 2 (Herpesvirus saimiri) is capable of inducing lethal T-cell lymphoproliferative diseases in primates and of immortalizing human T lymphocytes in vitro. Two viral oncoproteins, Tip and StpC, are essential for T-cell transformation by Herpesvirus saimiri strains of the subgroup C, which exhibits a higher transformation potential than other subgroups of this virus. Despite the importance of these proteins, the molecular basis of their effects on T cells is pearly understood. It remains unclear how Ti p and StpC affect gene expression a nd what is the molecular basis of their cooperation. To address these issues, we expressed Tip and StpC in T lymphoblastoid cells and assessed both their effects on and transcription factors involved in IL-2 gene expression. Our study shows that Tip and StpC cooperate to upregulate IL-2 gene expression, that their effect is mediated primarily by NF-KB and NF-AT, which is partially dependent on tyrosine phosphorylation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:47:51