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Titolo:
Alteration of CD44 and cadherins expression: possible association with augmented aggressiveness and invasiveness of endometrial carcinoma
Autore:
Leblanc, M; Poncelet, C; Soriano, D; Walker-Combrouze, F; Madelenat, P; Scoazec, JY; Darai, E;
Indirizzi:
Hop Bichat Claude Bernard, Serv Gynecol Obstet, F-75004 Paris, France Hop Bichat Claude Bernard Paris France F-75004 et, F-75004 Paris, France Univ Paris 07, Fac Med Xavier Bichat, INSERM, U327,Lab Biol Cellulaire, Paris, France Univ Paris 07 Paris France ERM, U327,Lab Biol Cellulaire, Paris, France Hop Bichat Claude Bernard, Serv Anat & Cytol Pathol, F-75877 Paris 18, France Hop Bichat Claude Bernard Paris France 18 thol, F-75877 Paris 18, France Hop Hotel Dieu, Gynecol Serv, F-75181 Paris, France Hop Hotel Dieu ParisFrance F-75181 Gynecol Serv, F-75181 Paris, France
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 438, anno: 2001,
pagine: 78 - 85
SICI:
0945-6317(200101)438:1<78:AOCACE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION; DIFFERENTIAL EXPRESSION; MYOMETRIAL INVASION; MENSTRUAL-CYCLE; CANCER; INTEGRINS; PROGRESSION; BORDERLINE; MANAGEMENT; BEHAVIOR;
Keywords:
cadherins; CD44; adhesion molecule; immunohistochemistry; endometrium; endometrial carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Darai, E Hop Bichat Claude Bernard, Serv Gynecol Obstet, 1 Parvis Notre Dame, F-75004 Paris, France Hop Bichat Claude Bernard 1 Parvis Notre Dame Paris France F-75004
Citazione:
M. Leblanc et al., "Alteration of CD44 and cadherins expression: possible association with augmented aggressiveness and invasiveness of endometrial carcinoma", VIRCHOWS AR, 438(1), 2001, pp. 78-85

Abstract

Cadherins and CD44 isoforms are transmembrane glycoproteins with diverse functions in cell-cell and cell-matrix interactions and may be a determinantof invasive and metastatic behavior in carcinomas. The immunohistochemicalexpression of cadherins and CD44 in tissue samples from 15 normal endometrium and 33 endometrial adenocarcinomas were examined. The immunohistochemical analysis was performed using the monoclonal antibody HECD-1 against E-cadherin and the polyclonal antibody against N-cadherin. In addition, the monoclonal antibodies 2C5, which binds to CD44s and all of the variants encoded by exons 3-10; 3G5, which is specific for CD44v3; and 2F10, which is specific for CD44v6 were used. E-cadherin (P=0.0001) and N-cadherin (P<0.001) expressions were statistically lower in endometrial adenocarcinoma than in normal endometrium. In contrast, an overexpression of CD44 isoforms (P<0.01)and CD34v3 (P<0.01) expressions was found in endometrial adenocarcinomas compared with normal endometrium. No difference was noted for CD44v6. An association was found between a decrease in E-cadherin expression and the occurrence of local recurrent and nodal metastasis. An association was found between CD44 overexpression, lymph space involvement, and myometrial invasion. Our results suggest that cadherin and CD44 expressions in endometrial carcinomas may have a prognostic value. Alteration of CD44 seems to be relatedto local invasion, while alteration of E-cadherin seems to be associated with dissemination of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:35:35