Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of monocyte chemoattractant protein-1 in peritoneal endometriotic cells
Autore:
Yih, S; Katabuchi, H; Araki, M; Matsuura, K; Takeya, M; Takahashi, K; Okamura, H;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Obstet & Gynecol, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 & Gynecol, Kumamoto 8608556, Japan Kumamoto Univ, Sch Med, Dept Pathol, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 ept Pathol, Kumamoto 8600811, Japan
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 438, anno: 2001,
pagine: 70 - 77
SICI:
0945-6317(200101)438:1<70:EOMCPI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOTACTIC PROTEIN-1; OVARIAN ENDOMETRIOSIS; INFERTILE WOMEN; FLUID; MACROPHAGES;
Keywords:
endometriosis; monocyte chemoattractant protein-1 macrophages; immunohistochemistry; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Katabuchi, H Kumamoto Univ, Sch Med, Dept Obstet & Gynecol, Honjo 1-1-1, Kumamoto 8608556, Japan Kumamoto Univ Honjo 1-1-1 Kumamoto Japan 8608556 8556, Japan
Citazione:
S. Yih et al., "Expression of monocyte chemoattractant protein-1 in peritoneal endometriotic cells", VIRCHOWS AR, 438(1), 2001, pp. 70-77

Abstract

It is well known that the number of peritoneal macrophages is increased inpatients with pelvic endometriosis. We measured the concentration of monocyte chemoattractant protein-1 (MCP-1) using an enzyme-linked immunosorbent assay (ELISA) in the peritoneal fluid of women with and without endometriosis. The expression of MCP-1 in pelvic endometriotic lesions obtained from the peritoneum was also examined using immunohistochemistry and nonradioactive in situ hybridization. The mean concentration of MCP-1 in the peritonealfluid was significantly higher in the patients with endometriosis (P<0.05). The most significant elevation, compared with non-endometriosis patients,was found in stage I of the disease (P<0.05). However, no statistically significant difference was found among endometriosis stages I, II, III, and IV. Immunohistochemical staining revealed that MCP-1-positive cells were localized in the glandular epithelium of the endometriotic lesions and in the stromal macrophages distributed in those lesions, but normal peritoneal cells were negative. The in situ hybridization method demonstrated expression of MCP-1 mRNA on the endometriotic glandular epithelium and stromal macrophages. These findings suggest that MCP-1 may be involved in the histogenesisand early development of peritoneal endometriosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:35:58