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Titolo:
Predicting exposure conditions that facilitate the potentiation of noise-induced hearing loss by carbon monoxide
Autore:
Fechter, LD; Chen, GD; Rao, D; Larabee, J;
Indirizzi:
Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Ctr Toxicol, Oklahoma City, OK 73190 USA Univ Oklahoma Oklahoma City OK USA 73190 col, Oklahoma City, OK 73190 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 58, anno: 2000,
pagine: 315 - 323
SICI:
1096-6080(200012)58:2<315:PECTFT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREQUENCY HEARING; OCCUPATIONAL EXPOSURE; THRESHOLD SHIFTS; AIR CONTAMINANTS; ORGANIC-SOLVENTS; METHYL MERCURY; OTOTOXICITY; TOLUENE; TRICHLOROETHYLENE; FIREFIGHTERS;
Keywords:
carbon monoxide; ototoxicity; chemical asphyxiants; noise; risk assessment; complex exposures; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Fechter, LD Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Ctr Toxicol, POB 26901, Oklahoma City, OK 73190 USA Univ Oklahoma POB 26901 Oklahoma City OK USA73190 K 73190 USA
Citazione:
L.D. Fechter et al., "Predicting exposure conditions that facilitate the potentiation of noise-induced hearing loss by carbon monoxide", TOXICOL SCI, 58(2), 2000, pp. 315-323

Abstract

Hearing loss is the most common occupational disease in the United States,with noise serving as the presumed causative agent in most instances. Thisinvestigation characterizes the exposure conditions that facilitate the potentiation of noise-induced hearing loss (NIHL) by carbon monoxide (CO), Auditory function was compared in rats exposed 4 weeks earlier to noise alone, CO alone, combined exposure, and air in the exposure chamber. This interval between exposure and auditory threshold assessment was selected to permit recovery of temporary threshold shifts. The compound action potential (CAP) threshold evoked by pure tone stimuli was used as a measure of auditory sensitivity. The no adverse effect level (NOAEL) with respect to potentiation of NIHL was found to be 300 ppm CO. Potentiation of NIHL by CO increaseslinearly as CO concentration increases between 500-1500 ppm. Benchmark dose software (version 1.1B) published by the U.S. EPA National Center for Environmental Assessment was employed to determine a benchmark concentration of CO that produced either a 5-dB potentiation of NIHL or an increase in auditory threshold equivalent to 10% of the effect of noise alone. The lower bound for these benchmark concentrations were 320 and 194 ppm CO, respectively, Unlike CO dose, the relationship between noise severity and potentiation of NIHL by CO shows a nonlinear relationship. The greatest potentiation was observed at moderate noise exposures (100 dB, 2-h, octave band-limited noise, or OBN) that produce limited permanent threshold shifts. Repeated exposures to 95-dB noise for 2-h periods in combination with 1200 ppm CO also yielded potentiation of NIHL, though such effects were not observed following a single combined exposure. These results underscore the potential risk of hearing loss from combined exposure to noise and CO, and the risks associated with repeated exposure.

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Documento generato il 02/04/20 alle ore 19:27:53