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Titolo:
Cognitive tests: Interpretation for neurotoxicity? (Workshop summary)
Autore:
Slikker, W; Beck, BD; Cory-Slechta, DA; Paule, MG; Anger, WK; Bellinger, D;
Indirizzi:
Gradient Corp, Cambridge, MA 02142 USA Gradient Corp Cambridge MA USA 02142 adient Corp, Cambridge, MA 02142 USA Natl Ctr Toxicol Res, Div Neurotoxicol, Jefferson, AR 72079 USA Natl Ctr Toxicol Res Jefferson AR USA 72079 icol, Jefferson, AR 72079 USA Univ Rochester, Sch Med, Dept Environm Med, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 vironm Med, Rochester, NY 14642 USA Natl Ctr Toxicol Res, Div Neurotoxicol, Behav Toxicol Lab, Jefferson, AR 72079 USA Natl Ctr Toxicol Res Jefferson AR USA 72079 Lab, Jefferson, AR 72079 USA Oregon Hlth Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 oxicol, Portland, OR 97201 USA Childrens Hosp, Neuroepidemiol Unit, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 roepidemiol Unit, Boston, MA 02115 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 58, anno: 2000,
pagine: 222 - 234
SICI:
1096-6080(200012)58:2<222:CTIFN(>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPEATED ACQUISITION; RHESUS-MONKEYS; SUSTAINED ATTENTION; RESPONSE SEQUENCES; SAMPLE PERFORMANCE; CHILD-DEVELOPMENT; LEAD-EXPOSURE; DELAYED MATCH; TEST BATTERY; RATS;
Keywords:
cognitive tests; behavioral neurotoxicology; metals; solvents; neurobehavioral test battery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Beck, BD Gradient Corp, 238 Main St, Cambridge, MA 02142 USA Gradient Corp238 Main St Cambridge MA USA 02142 ge, MA 02142 USA
Citazione:
W. Slikker et al., "Cognitive tests: Interpretation for neurotoxicity? (Workshop summary)", TOXICOL SCI, 58(2), 2000, pp. 222-234

Abstract

The appropriate use and interpretation of cognitive tests presents important challenges to the toxicologist and to the risk assessor. For example, intelligence cannot be measured directly; rather intelligence is quantified indirectly by scoring responses (i.e., behaviors) to specific situations (problems), This workshop, "Cognitive Tests: Interpretation for Neurotoxicity?" provided an overview on the types of cognitive tests available and described approaches by which the validity of such tests can be assessed. Unlike many tools available to the toxicologist, cognitive tests have a particularadvantage. Being noninvasive and species-neutral, the same test can be performed in different mammalian species. This enhances one's ability to assess the validity of test results. Criteria for test validity include comparable responses across species as well as similar disruption by the same neurotoxicant across species, Test batteries, such as the Operant Test Battery, have indicated remarkable similarity between monkeys and children with respect to performance of certain tasks involving, for example, short-term memory. Still, there is a need for caution in interpretation of such tests, In particular, cognitive tests, especially when performed in humans, are subject to confounding by a range of factors, including age, gender, and, in particular, education. Moreover, the ability of such tests to reflect intelligence must be considered. Certain aspects of intelligence, such as the ability to plan or carry out specific tasks, are not well reflected by many of the standard tests of cognition. Nonetheless, although still under development, cognitive tests do hold promise for reliably predicting neurotoxicity in humans.

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Documento generato il 23/01/20 alle ore 18:16:49