Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice
Autore:
Fornai, F; Giorgi, FS; Gesi, M; Chen, K; Alessandri, MG; Shih, JC;
Indirizzi:
Univ Pisa, Dept Human Morphol & Appl Biol, I-56126 Pisa, Italy Univ Pisa Pisa Italy I-56126 an Morphol & Appl Biol, I-56126 Pisa, Italy INM Neurmed, IRCCS, Pozzilli, Italy INM Neurmed Pozzilli ItalyINM Neurmed, IRCCS, Pozzilli, Italy Univ So Calif, Sch Pharm, Dept Mol Pharmacol & Toxicol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Toxicol, Los Angeles, CA 90033 USA Univ Pisa, INPE, IRCCS Stella Maris, Pisa, Italy Univ Pisa Pisa ItalyUniv Pisa, INPE, IRCCS Stella Maris, Pisa, Italy Univ So Calif, Sch Med, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 urobiol, Los Angeles, CA 90033 USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 39, anno: 2001,
pagine: 213 - 221
SICI:
0887-4476(20010301)39:3<213:BEOTMN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDASE-B; METHYLENEDIOXYMETHAMPHETAMINE MDMA; DOPAMINERGIC NEUROTOXICITY; RAT-BRAIN; INHIBITION; METHAMPHETAMINE; DEPLETION; SEROTONIN; NEURONS; AMPHETAMINE;
Keywords:
dopamine; ecstasy; knockout; norepinephrine; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Fornai, F Univ Pisa, Dept Human Morphol & Appl Biol, Via Roma 55, I-56126 Pisa, Italy Univ Pisa Via Roma 55 Pisa Italy I-56126 5, I-56126 Pisa, Italy
Citazione:
F. Fornai et al., "Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice", SYNAPSE, 39(3), 2001, pp. 213-221

Abstract

Previous studies reported that drugs acting as monoamine oxidase (MAO)-B inhibitors prevented biochemical effects induced by the neurotoxins N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) and 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). In this study, we administered DSP-4 (50 mg/kg) or MDMA (50 mg/kg X2, 2 h apart) to MAO-B deficient mice. Monoamine contentin various brain regions (cerebellum, frontal cortex, hippocampus, hypothalamus, striatum, substantia nigra) was assayed 1 week after neurotoxin administration. Injection of DSP-4 to wild-type mice caused a marked norepinephrine (NE) loss in specific brain regions. Unexpectedly, DSP-4 caused similar effects in MAO-B-deficient and in wild-type mice in all brain regions investigated. These results suggest that MAO-B is not involved in DSP-4 toxicity. In wild-types, the neurotoxin MDMA induced both serotonin (5HT) and dopamine (DA) depletion in specific brain areas. In MAO-B-deficient mice, 5HT depletion observed in wild-types did not occur. In contrast, MDMA produced a more pronounced DA loss in knockout mice compared with wild-types. The present findings, together with previous data obtained using selective enzymeinhibitors, suggest that MAO-B is not involved in the mechanism of action of DSP-4, whereas it plays opposite roles in MDMA-induced DA and 5HT depletions. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 17:24:36