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Titolo:
Ethnic differences in C-peptide levels and anti-GAD antibodies in South African patients with diabetic ketoacidosis
Autore:
Rheeder, P; Stolk, RP; Grobbee, DE;
Indirizzi:
Univ Pretoria, Dept Internal Med, Medihelp Chair Clin Epidemiol, ZA-0001 Pretoria, South Africa Univ Pretoria Pretoria South Africa ZA-0001 -0001 Pretoria, South Africa Univ Utrecht, Julius Ctr Gen Practice & Patient Oriented Res, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 1, volume: 94, anno: 2001,
pagine: 39 - 43
SICI:
1460-2725(200101)94:1<39:EDICLA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; INSULIN REQUIREMENT; ISLET-CELL; BLACK; AMERICANS; OBESE; MELLITUS; TYPE-2; NIDDM; AUTOANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Rheeder, P Univ Pretoria, Dept Internal Med, Medihelp Chair Clin Epidemiol, POB 667, ZA-0001 Pretoria, South Africa Univ Pretoria POB 667 Pretoria South Africa ZA-0001 uth Africa
Citazione:
P. Rheeder et al., "Ethnic differences in C-peptide levels and anti-GAD antibodies in South African patients with diabetic ketoacidosis", QJM-MON J A, 94(1), 2001, pp. 39-43

Abstract

To determine differences between Black and White South Africans with diabetic ketoacidosis (DKA) and between Black patients on insulin vs. those on oral agents presenting with DKA, post stabilization fasting C-peptide levelsand anti-glutamic acid decarboxylase (GAD) antibodies were measured together with serum glucose, acid base and urine ketones on admission. Of 60 patients with diabetic ketoacidosis (DKA) (76 admissions), the 43 Black patients had a higher BMI (23.1 vs. 20.0 kg/m(2), p=0.05) than did the 17 White patients, were more often newly diagnosed (37% vs. 1%, p=0.03), and a greaterproportion of Black patients had fasting C-peptide levels > 0.3 nmol/l (28% (10/36) vs. 0%, p=0.03). Of these 10 Black patients, eight were anti-GAD-negative. Thirteen Black patients (33%) were anti-CAD-positive vs. 10 (67%)White patients (p=0.03). There was no statistically significant differencein anti-CAD positivity between Black patients on oral agents or those on insulin. Most patients (5/7) admitted on oral agents had negative C-peptide levels after stabilization. Our results suggest that in patients presentingwith DKA, a quarter of Black South Africans have C-peptide levels regardedas being indicative of type 2 DM and are less frequently anti-CAD-antibody-positive than are White South Africans.

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Documento generato il 31/03/20 alle ore 16:25:25