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Titolo:
Acute tryptophan depletion in schizophrenia
Autore:
Golightly, KL; Lloyd, JA; Hobson, JE; Gallagher, P; Mercer, G; Young, AH;
Indirizzi:
Univ Newcastle Upon Tyne, Div Psychiat, Sch Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon TyneTyne & Wear England NE1 7RU
Titolo Testata:
PSYCHOLOGICAL MEDICINE
fascicolo: 1, volume: 31, anno: 2001,
pagine: 75 - 84
SICI:
0033-2917(200101)31:1<75:ATDIS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA TRYPTOPHAN; ANTIDEPRESSANT ACTION; SEROTONIN FUNCTION; NEGATIVE SYMPTOMS; RAPID DEPLETION; D-FENFLURAMINE; RECEPTORS; CLOZAPINE; SCALE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Young, AH Royal Victoria Infirm, Div Psychiat, Sch Neurosci & Psychiat, Leazes Wing,Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Leazes Wing Newcastle Upon Tyne Tyne & Wear England NE1 4LP
Citazione:
K.L. Golightly et al., "Acute tryptophan depletion in schizophrenia", PSYCHOL MED, 31(1), 2001, pp. 75-84

Abstract

Background. Brain 5-hydroxytryptamine (5-HT) function is implicated in thepathophysiology of schizophrenia and the action of new generation antipsychotic drugs. By the method of acute tryptophan depletion (ATD) 5-HT can be selectively manipulated. The aim of this study was to examine the effects of ATD on symptoms, mood and cognition in schizophrenic patients. Methods. Twenty-eight schizophrenic patients participated in a within subject, double-blind, placebo-controlled counterbalanced cross-over study. Patients with a concurrent DSM-IV axis I diagnosis were excluded. Symptoms, mood and cognitive function were evaluated following ATD or ingestion of a control drink. Results. The depleting drink significantly reduced plasma total and free tryptophan. Tryptophan/LNAA ratios did not alter with the administration of the control drink, but differed significantly with ATD; however there was no significant change in tyrosine/LNAA ratio. ATD led to impairment in executive function that was dependent upon the order of administration. Tests ofsustained attention, speed of processing, and everyday memory were not affected. No effects were observed on subjective mood ratings, movement disorders or PANSS scores. Conclusions. Acute tryptophan depletion selectively alters cognition in schizophrenia, but has no effect on symptoms, mood ratings or movement disorders.

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Documento generato il 19/01/20 alle ore 09:21:32