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Titolo:
A peripheral marker for schizophrenia: Increased levels of D-3 dopamine receptor mRNA in blood lymphocytes
Autore:
Ilani, T; Ben-Shachar, D; Strous, RD; Mazor, M; Sheinkman, A; Kotler, M; Fuchs, S;
Indirizzi:
Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 unol, IL-76100 Rehovot, Israel Technion Israel Inst Technol, Rambam Med Ctr, IL-31096 Haifa, Israel Technion Israel Inst Technol Haifa Israel IL-31096 L-31096 Haifa, Israel Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel Technion Israel Inst Technol Haifa Israel IL-31096 L-31096 Haifa, Israel Beer Yaacov Mental Hlth Ctr, IL-70300 Beer Yaacov, Israel Beer Yaacov Mental Hlth Ctr Beer Yaacov Israel IL-70300 r Yaacov, Israel Mental Hlth Ctr, IL-30200 Haifa, Israel Mental Hlth Ctr Haifa Israel IL-30200 l Hlth Ctr, IL-30200 Haifa, Israel
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 2, volume: 98, anno: 2001,
pagine: 625 - 628
SICI:
0027-8424(20010116)98:2<625:APMFSI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Fuchs, S Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
T. Ilani et al., "A peripheral marker for schizophrenia: Increased levels of D-3 dopamine receptor mRNA in blood lymphocytes", P NAS US, 98(2), 2001, pp. 625-628

Abstract

Dopamine is a major neurotransmitter in the central nervous system, and its receptors are associated with a number of neuropathological disorders such as Parkinson's disease and schizophrenia. Although the precise pathophysiology of schizophrenia remains unknown, the dopaminergic hypothesis of the illness assumes that the illness results from excessive activity at dopamine synapses in the brain. Because, at present, the diagnosis of schizophrenia relies on descriptive behavioral and symptomatic information, a peripheral measurable marker may enable a simpler, more rapid, and more accurate diagnosis and monitoring. In recent years, human peripheral blood lymphocytes have been found to express several dopamine receptors (D-3, D-4, and D-5) by using molecular biology techniques and binding assays. It has been suggested that these dopamine receptors found on lymphocytes may reflect receptors found in the brain. Here we demonstrate a correlation between the D-3 dopamine receptor on lymphocytes and schizophrenia and show a significant elevation of at least 2-fold in the mRNA level of the D-3, but not of the D4, dopamine receptor in schizophrenic: patients. This increase is not affected by different antipsychotic. drug treatments (typical or atypical). Moreover, nonmedicated patients exhibit the same pattern, indicating that this change is not a result of medical treatment. We propose the D-3 receptor mRNA on blood lymphocytes as a marker for identification and followup of schizophrenia.

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Documento generato il 29/03/20 alle ore 14:20:34