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Titolo:
Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues
Autore:
Kobayashi, T; Ohta, Y; Yoshino, J; Nakazawa, S;
Indirizzi:
Fujita Hlth Univ, Sch Med, Dept Chem, Toyoake, Aichi 47011, Japan Fujita Hlth Univ Toyoake Aichi Japan 47011 m, Toyoake, Aichi 47011, Japan Fujita Hlth Univ, Sch Med, Teaching Hosp 2, Dept Internal Med, Nagoya, Aichi 4548509, Japan Fujita Hlth Univ Nagoya Aichi Japan 4548509 Nagoya, Aichi 4548509, Japan
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 1, volume: 43, anno: 2001,
pagine: 23 - 30
SICI:
1043-6618(200101)43:1<23:TPTHOA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; MUCOSAL LESIONS; NITRIC-OXIDE; ANTIULCER AGENT; POLYMORPHONUCLEAR LEUKOCYTES; FREE-RADICALS; MUCUS; GERANYLGERANYLACETONE; TETRAPRENYLACETONE; MYELOPEROXIDASE;
Keywords:
teprenone; anti-ulcer drug; gastric ulcer healing; neutrophil infiltration; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Ohta, Y Fujita Hlth Univ, Sch Med, Dept Chem, Toyoake, Aichi 47011, Japan Fujita Hlth Univ Toyoake Aichi Japan 47011 ke, Aichi 47011, Japan
Citazione:
T. Kobayashi et al., "Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues", PHARMAC RES, 43(1), 2001, pp. 23-30

Abstract

Teprenone, an anti-ulcer drug, has been reported to promote the healing ofacetic acid-induced chronic gastric ulcers in rats by stimulating gastric mucus synthesis and secretion. Recently, it has been implicated that neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues have an inhibitory effect on the healing of acetic acid-induced chronic gastric ulcers in rats. Therefore, we attempted to clarify whether teprenone exertsa healing-promoting effect on acetic acid-induced chronic gastric ulcers through its inhibitory effect on neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues. In rats with chronic gastric ulcers made by applying acetic acid to the stomach, gastric ulcer healing started laterthan 3 days after the acetic acid application. Gastric mucosal myeloperoxidase (MPO) activity, an index of tissue neutrophil infiltration, and lipid peroxide content were higher in the ulcerated region than in the intact region on the 8th, 15th, and 22nd day after the acetic acid application. Gastric mucosal non-protein SH content was lower in the ulcerated region than inthe intact region on the 8th, 15th, and 22nd day after the acetic acid application, and gastric mucosal adherent mucus content was lower in the ulcerated region than in the intact region on the 8th and 15th day. Daily oral administration of teprenone (100 mg kg(-1) x 2) for 7 or 14 days, starting on the 8th day after the application of acetic acid to the stomach, enhancedthe reduction of the ulcer area with attenuation of all these biochemical changes found in the ulcerated region. The teprenone administration caused a decrease in MPO activity and an increase in adherent mucus content in thegastric mucosa of the intact region. These results suggest that the healing-promoting effect of teprenone on acetic acid-induced chronic gastric ulcers in rats could be due not only to stimulation of gastric mucus secretion but also to inhibition of neutrophil infiltration and enhanced lipid peroxidation in the ulcerated gastric tissue. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:24:43