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Titolo:
New conformationally restricted analog of the immunosuppressory mini-domain of HLA-DQ and its biological properties
Autore:
Szewczuk, Z; Wilczynski, A; Dyba, M; Petry, I; Siemion, IZ; Wieczorek, Z;
Indirizzi:
Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-50383 Fac Chem, PL-50383 Wroclaw, Poland Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland Polish Acad Sci Wroclaw Poland PL-53114 herapy, PL-53114 Wroclaw, Poland
Titolo Testata:
PEPTIDES
fascicolo: 12, volume: 21, anno: 2000,
pagine: 1849 - 1858
SICI:
0196-9781(200012)21:12<1849:NCRAOT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4 BINDING; CRYSTAL-STRUCTURE; PROTEIN HLA-DR1; DR MOLECULES; PEPTIDE; IDENTIFICATION; NOMENCLATURE; INHIBITORS; FRAGMENTS; SEQUENCE;
Keywords:
histocompatibility antigen; thymopentin analogs; immunosuppressors; RGD sequence; cyclic peptide analog; proteolytic stability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Szewczuk, Z Univ Wroclaw, Fac Chem, Ul F Joliot Curie 14, PL-50383 Wroclaw, Poland Univ Wroclaw Ul F Joliot Curie 14 Wroclaw Poland PL-50383 and
Citazione:
Z. Szewczuk et al., "New conformationally restricted analog of the immunosuppressory mini-domain of HLA-DQ and its biological properties", PEPTIDES, 21(12), 2000, pp. 1849-1858

Abstract

Our previous studies revealed that the nonapeptide fragment of HLA-DQ located in the beta 164-172 loop of the Thr-Pro-Gln-Arg-Gly-Asp-Val-Tyr-Thr sequence suppresses the immune humoral and cellular responses [30]. Based on the crystal structure of HLA-class Il molecules we designed and synthesized a cyclic analog with restricted conformation, cyclo(Suc-Thr-Pro-Gln-Arg-Gly-Asp-Val-Lys)-Thr-OH (Suc = succinyl) by reacting a Lys side chain with a succinylated N-terminus. The cyclization product more potently suppresses the cellular immune response than its linear counterparts and is efficiently cleaved by trypsin. The results indicate that the beta 164-172 loop may serve as a functional epitope on the HLA class II surface for intermolecular binding. (C) 2000 Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:22:00