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Titolo:
Restenosis after balloon angioplasty of coarctation: Relationship with ductus arteriosus
Autore:
Takahashi, K; Ino, T; Ohkubo, M; Akimoto, K; Kishirou, M;
Indirizzi:
Juntendo Univ, Sch Med, Dept Pediat, Bunkyo Ku, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 , Dept Pediat, Bunkyo Ku, Tokyo 113, Japan Kameda Med Ctr, Dept Pediat, Chiba, Japan Kameda Med Ctr Chiba JapanKameda Med Ctr, Dept Pediat, Chiba, Japan
Titolo Testata:
PEDIATRICS INTERNATIONAL
fascicolo: 6, volume: 42, anno: 2000,
pagine: 658 - 667
SICI:
1328-8067(200012)42:6<658:RABAOC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAVY-CHAIN ISOFORM; NATIVE AORTIC COARCTATION; SMOOTH-MUSCLE CELLS; VASCULAR DEVELOPMENT; FOLLOW-UP; EXPRESSION; DILATATION; ARTERIOSCLEROSIS; RECOARCTATION; RABBITS;
Keywords:
balloon angioplasty; coarctation; ductus arteriosus; myosin heavy chain; smooth muscle cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ohkubo, M Juntendo Univ, Sch Med, Dept Pediat, Bunkyo Ku, 2-1-1 Hongo, Tokyo 113, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 113 ngo, Tokyo 113, Japan
Citazione:
K. Takahashi et al., "Restenosis after balloon angioplasty of coarctation: Relationship with ductus arteriosus", PEDIATR INT, 42(6), 2000, pp. 658-667

Abstract

Background: Recently, balloon angioplasty (BA) has been used for the treatment of coarctation of the aorta (CoA) and the effectiveness of this treatment has been reported. However, the restenosis rate following BA in native CoA in the infant is high and the cause may be related to tissue propertiesat the origin of the ductus arteriosus (DA). However, the mechanisms responsible for restenosis remain uncertain. Methods/Results: The present study was designed to examine transformation of the smooth muscle cell (SMC) phenotypes using immunohistologic studies and to investigate the cause of restenosis of CoA following BA. A CoA model was surgically created in 15 newborn pigs (10-14-days-old; 2.4-4.1 kg). Balloon angioplasty was performed 1 month after the initial operation. One or 3 months after BA, animals were killed and immunohistologic studies on smooth muscle cell (SMC) antibodies against SMI, SM2 and SMemb of the myosin heavy chain (MHC) isoform were performed in the aorta at the CoA and DA. In the neointima, only SMemb was positive. In the SMC layer of the DA, only SM2was positive. One month after BA, the external layer of the tunica media was strongly positive for SM2 only in the area around the origin of the DA. Conclusions: The first cause of restenosis is obstructive neointimal formation caused by the proliferation of undifferentiated SMC into the subendothelial tissue. This proliferation seems to be triggered by BA. The distribution of SM2 1 month after balloon angioplasty showed a similar pattern of proliferation of SMC in the external layer around the DA. This may represent a second mechanism of restenosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:31:20