Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy
Autore:
Henson, BS; Inglehart, MR; Eisbruch, A; Ship, JA;
Indirizzi:
Univ Michigan, Sch Dent, Dept Oral Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Oral Med, Ann Arbor, MI 48109 USA Univ Michigan, Sch Dent, Dept Periodont, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Periodont, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 adiat Oncol, Ann Arbor, MI 48109 USA
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 1, volume: 37, anno: 2001,
pagine: 84 - 93
SICI:
1368-8375(200101)37:1<84:PSOAXQ>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE STATUS SCALE; OF-LIFE; RADIATION-THERAPY; CONCOMITANT CHEMORADIOTHERAPY; EUROPEAN-ORGANIZATION; ORAL CAVITY; FLOW-RATES; IRRADIATION; QUESTIONNAIRE; VALIDATION;
Keywords:
xerostomia; saliva; radiotherapy; cancer; preservation; longitudinal; parotid; quality of life;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Ship, JA NYU, Coll Dent, Med Surg & Clin Res Ctr, Div Biol Sci, 345 E 24thSt, New York, NY 10010 USA NYU 345 E 24th St New York NY USA 10010 t, New York, NY 10010 USA
Citazione:
B.S. Henson et al., "Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy", ORAL ONCOL, 37(1), 2001, pp. 84-93

Abstract

Radiotherapy (RT) for head and neck cancers causes salivary dysfunction and diminished xerostomia-related quality of life. We have demonstrated that three-dimensional treatment planning and conformational doss-delivery techniques can minimize RT doses to contralateral parotid glands while providingtherapeutic doses to tumors. This study's purpose was to assess parotid salivary function up to 1 year post-RT in patients receiving bilateral neck parotid-sparing RT, and to determine if parotid preservation would significantly improve xerostomia-related quality of life. Unstimulated (UPFR) and stimulated (SPFR) parotid flow rates were collected from 20 head and neck cancer patients. All subjects completed a 15-item xerostomia-related quality of life scale (XeQoLS) prior to RT, at the completion of RT, 1, 3, 6 and 12 months post-RT. Salivary flow rates from spared and treated glands were significantly decreased at the completion of RT. After RT completion, spared UPFR and SPFR function increased and was not significantly different from baseline values. Output from treated glands remained statistically indistinguishable from zero throughout the post-RT period. Subjects had a significantly worse xerostomia-related quality of life at the completion of RT compared to baseline, and XeQoLS responses improved significantly 1 month post-RT. Responses at 1 year were markedly better than at the completion of RT, butstill significantly worst than baseline. These findings suggest that despite parotid-sparing RT, salivary flow rates from treated and spared glands and xerostomia-related quality of life decrease at the completion of RT. However, with the use of parotid-sparing RT, contralateral glands are preserved at 1 year post-RT with a concomitant improvement in xerostomia-related quality of life. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:23:56