Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro
Autore:
Yokoyama, K; Kamata, N; Hayashi, E; Hoteiya, T; Ueda, N; Fujimoto, R; Nagayama, M;
Indirizzi:
Univ Tokushima, Sch Dent, Dept Oral & Maxillofacial Surg 1, Tokushima 770,Japan Univ Tokushima Tokushima Japan 770 llofacial Surg 1, Tokushima 770,Japan
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 1, volume: 37, anno: 2001,
pagine: 65 - 71
SICI:
1368-8375(200101)37:1<65:RCOEAS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; INVASIVE PHENOTYPE; ESOPHAGEAL CANCER; HUMAN BREAST; GENE; DROSOPHILA; CATENIN; KERATINOCYTES; METASTASIS; LINES;
Keywords:
SCC; invasion; E-cadherin; catenin; snail;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kamata, N Univ Tokushima, Sch Dent, Dept Oral & Maxillofacial Surg 1, Tokushima 770,Japan Univ Tokushima Tokushima Japan 770 Surg 1, Tokushima 770,Japan
Citazione:
K. Yokoyama et al., "Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro", ORAL ONCOL, 37(1), 2001, pp. 65-71

Abstract

The loss of E-cadherin expression has been shown to correlate to the invasion and metastasis of many types of carcinomas. We established E-cadherin positive (HOC719-PE) and negative (HOC719-NE) clones from an oral squamous cell carcinoma (SCC). HOC719-PE cells showed epithelial morphology with E-cadherin expression in the cell membrane, whereas HOC719-NE cells demonstrated fibroblastic morphology without E-cadherin expression. In invasion assay and three dimensional culture, HOC719-NE showed much higher invasive ability than HOC719-PE cells. These cells expressed similar levels of mRNAs for alpha- and beta -catenin. However, HOC719-NE cells, bur not HOC719-PE cells,showed strong expression of snail, a transcription factor implicated in the differentiation of epithelial cells into mesenchymal phenotype. This reverse expression of snail and E-cadherin was further observed in other SCC cells including HOC313, and TSU cells that we previously reported to show no expression of E-cadherin protein. These results indicated that the expression of snail has a key role for the acquisition of more invasive and metastatic phenotypes of SCC and the clones we reported here will be useful tools for understanding the mechanism of the transition from epithelial to mesenchymal SCC cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:35:56